Background Despite its common use in cancer treatment, radiotherapy has not yet entered
the era of precision medicine, and there have been no approaches to adjust dose based on …

The increasing rate of antibiotic resistance and slowing discovery of novel antibiotic treatments
presents a growing threat to public health. Here, we consider a simple model of evolution …

Recent advances in clinical medicine have elucidated two significantly different subtypes of
glioblastoma which carry very different prognoses, both defined by mutations in isocitrate …

Radiomics describes a broad set of computational methods that extract quantitative features
from radiographic images. The resulting features can be used to inform imaging diagnosis, …

The interpretation of large-scale protein network data depends on our ability to identify
significant substructures in the data, a computationally intensive task. Here we adapt and extend …

Background Despite advances in cancer genomics, radiotherapy is still prescribed on the
basis of an empirical one-size-fits-all paradigm. Previously, we proposed a novel algorithm …

… JACOB SCOTf* … * Yale Law School, JD; Williams College, BA © 2010, Jacob Scott. For
their helpful feedback, I am grateful to Alexander Berlin, Allison Dahl, William J. Durkin …

Whether the nom de guerre is Mathematical Oncology, Computational or Systems Biology,
Theoretical Biology, Evolutionary Oncology, Bioinformatics, or simply Basic Science, there is …

Whole brain radiotherapy (WBRT) is a mainstay of treatment in patients with both identifiable
brain metastases and prophylaxis for microscopic disease. The use of WBRT has …

Antibiotic resistance represents a growing health crisis that necessitates the immediate
discovery of novel treatment strategies. One such strategy is the identification of collateral …