Lysosomal sequestration of anti-cancer compounds reduces drug availability at intracellular
target sites, thereby limiting drug-sensitivity and inducing chemoresistance. For …

Background Idiopathic pulmonary fibrosis (IPF) is a chronic fatal lung disease without a cure
and new drug strategies are urgently needed. Differences in behavior between diseased …

The small non-coding VTRNA1-1 (vault RNA 1–1) is known to confer resistance to apoptosis
in several malignant cell lines and to also modulate the macroautophagic/autophagic flux in …

The DNA damage response (DDR) is intertwined with signaling pathways downstream of
oncogenic receptor tyrosine kinases (RTKs). To drive research into the application of targeted …

Poor oxygenation is a common hallmark of solid cancers that strongly associates with
aggressive tumor progression and treatment resistance. While a hypoxia-inducible factor 1α (HIF-…

In this study, 47 antibiotic-resistant strains of Salmonella enterica subspecies enterica serovar
Typhimurium (ST) were characterised, including 15 monophasic variants 1, 4,[5], 12: i:-,(…

The LIM‐domain protein Ajuba is associated with cell proliferation, a fundamental process
of tissue regeneration and cancer. We report that in the liver, Ajuba expression is increased …

The small non-coding vault RNA (vtRNA) 1-1 has been shown to confer apoptosis resistance
in several malignant cell lines and also to modulate the autophagic flux in hepatocytes, …

… Kristina Krempaska1,2,3, Sandra Barnowski1,2, Jacopo Gavini4, Nina Hobi5,6, Simone
Ebener1,2, Cedric Simillion2,7, Andrea Stokes1,2, Ronja Schliep8, Lars Knudsen8,9 …

Objective Circulating Proprotein convertase subtilisin/kexin type 9 (PCSK9) captured the
scientific community's attention as powerful target to fight against high serum cholesterol and its …