User profiles for Jacqueline A Quandt
 | Jacqueline QuandtUniversity of British Columbia Verified email at pathology.ubc.ca Cited by 1352 |
Structure of a human autoimmune TCR bound to a myelin basic protein self‐peptide and a multiple sclerosis‐associated MHC class II molecule
Multiple sclerosis is mediated by T‐cell responses to central nervous system antigens such
as myelin basic protein (MBP). To investigate self‐peptide/major histocompatibility complex (…
as myelin basic protein (MBP). To investigate self‐peptide/major histocompatibility complex (…
From the prodromal stage of multiple sclerosis to disease prevention
A prodrome is an early set of signs or symptoms that indicate the onset of a disease before
more typical symptoms develop. Prodromal stages are well recognized in some neurological …
more typical symptoms develop. Prodromal stages are well recognized in some neurological …
[HTML][HTML] Exome sequencing in multiple sclerosis families identifies 12 candidate genes and nominates biological pathways for the genesis of disease
Multiple sclerosis (MS) is an inflammatory disease of the central nervous system characterized
by myelin loss and neuronal dysfunction. Although the majority of patients do not present …
by myelin loss and neuronal dysfunction. Although the majority of patients do not present …
Magnetic resonance imaging of labeled T‐cells in a mouse model of multiple sclerosis
SA Anderson, J Shukaliak‐Quandt… - Annals of Neurology …, 2004 - Wiley Online Library
Multiple sclerosis (MS) is a T cell–mediated autoimmune disease with early lesions
characterized by mononuclear cellular infiltrate, edema, demyelination, and axonal loss that …
characterized by mononuclear cellular infiltrate, edema, demyelination, and axonal loss that …
[HTML][HTML] SPARC expression by cerebral microvascular endothelial cells in vitro and its influence on blood-brain barrier properties
…, L Zhou, J Roskams, P Rieckmann, JA Quandt - Journal of …, 2016 - Springer
Background SPARC (secreted protein acidic and rich in cysteine) is a nonstructural, cell-matrix
modulating protein involved in angiogenesis and endothelial barrier function, yet its …
modulating protein involved in angiogenesis and endothelial barrier function, yet its …
Serum neurofilament light chain correlates with myelin and axonal magnetic resonance imaging markers in multiple sclerosis
… JA Quandt has received research funding from Teva Neuroscience, the MS Society of
Canada, the National MS Society, the Milan & Maureen Ilich Foundation and the VGH and UBC …
Canada, the National MS Society, the Milan & Maureen Ilich Foundation and the VGH and UBC …
Myelin basic protein-specific TCR/HLA-DRB5* 01: 01 transgenic mice support the etiologic role of DRB5* 01: 01 in multiple sclerosis
Genetic susceptibility to multiple sclerosis (MS) has been linked to the HLA-DR15 haplotype
consisting of DRB1* 15: 01 (DR2b) and DRB5* 01: 01 (DR2a) alleles. Given almost …
consisting of DRB1* 15: 01 (DR2b) and DRB5* 01: 01 (DR2a) alleles. Given almost …
[HTML][HTML] Oral administration of the nitroxide radical TEMPOL exhibits immunomodulatory and therapeutic properties in multiple sclerosis models
…, M Cherukuri, JB Mitchell, JA Quandt - Brain, behavior, and …, 2017 - Elsevier
Therapies with both immunomodulatory and neuroprotective properties are thought to have
the greatest promise in reducing the severity and progression of multiple sclerosis (MS). …
the greatest promise in reducing the severity and progression of multiple sclerosis (MS). …
Unique clinical and pathological features in HLA-DRB1* 0401–restricted MBP 111–129–specific humanized TCR transgenic mice
Amino acid residues 111–129 represent an immunodominant epitope of myelin basic protein
(MBP) in humans with human leukocyte antigen (HLA)-DRB1*0401 allele(s). The MBP 111…
(MBP) in humans with human leukocyte antigen (HLA)-DRB1*0401 allele(s). The MBP 111…
Disease progression after bone marrow transplantation in a model of multiple sclerosis is associated with chronic microglial and glial progenitor response
…, J Schmidt, J Huh, JA Quandt… - … of Neuropathology & …, 2007 - academic.oup.com
Multiple sclerosis (MS), the most common nontraumatic cause of neurologic disability in
young adults in economically developed countries, is characterized by inflammation, gliosis, …
young adults in economically developed countries, is characterized by inflammation, gliosis, …