User profiles for Jacqueline F. Pelham

Jacqueline F Pelham

Cori Fellow, Department of Biochemistry and Molecular Biophysics, Washington University …
Verified email at wustl.edu
Cited by 66

[HTML][HTML] Intrinsic disorder is an essential characteristic of components in the conserved circadian circuit

JF Pelham, JC Dunlap, JM Hurley - Cell Communication and Signaling, 2020 - Springer
Introduction The circadian circuit, a roughly 24 h molecular feedback loop, or clock, is conserved
from bacteria to animals and allows for enhanced organismal survival by facilitating the …

Characterizing time-of-day conformational changes in the intrinsically disordered proteins of the circadian clock

JF Pelham, AE Mosier, JM Hurley - Methods in Enzymology, 2018 - Elsevier
Circadian rhythms are 24-h oscillations conserved in nearly all living organisms that allow
for the anticipation of daily environmental changes. These rhythms are maintained by a …

The formation of a fuzzy complex in the negative arm regulates the robustness of the circadian clock

MS Jankowski, D Griffith, DG Shastry, JF Pelham… - bioRxiv, 2022 - biorxiv.org
The circadian clock times cellular processes to the day/night cycle via a Transcription-Translation
negative Feedback Loop (TTFL). However, a mechanistic understanding of the …

[PDF][PDF] Conformational changes in the negative arm of the circadian clock correlate with dynamic interactomes involved in post-transcriptional regulation

JF Pelham, AE Mosier, SC Altshuler, ML Rhodes… - Cell reports, 2023 - cell.com
Biology is tuned to the Earth's diurnal cycle by the circadian clock, a transcriptional/translational
negative feedback loop that regulates physiology via transcriptional activation and other …

[PDF][PDF] LOCATE reveals electrostatic “islands” and “hotspots” are important for a disordered clock protein's interactions to regulate clock robustness

MS Jankowski, D Griffith, DG Shastry, JF Pelham… - Biophysical …, 2022 - cell.com
Many important biological processes are regulated by the circadian molecular clock, a negative
feedback loop comprised of disordered proteins. The lack of a fixed conformation means …

Intrinsic disorder plays a role in conserving the circadian circuit

JF Pelham, JC Dunlap, JM Hurley - 2020 - researchsquare.com
Over billions of years of evolution, the rhythm of Earth’s day and night–the diurnal cycle–has
remained one of very few constants. As a result, all kingdoms of life have evolved internal …

Deciphering the contributions of protein disorder to the repressing complex of the circadian clock

JF Pelham - 2022 - search.proquest.com
Circadian rhythms are biological oscillations that coordinate organismal physiology with the
Earth’s 24 hr. light/dark cycle. These rhythms are orchestrated by a core set of activating and …

A fuzzy complex in the negative arm regulates circadian clock robustness.

J Hurley, M Jankowski, D Griffith, D Shastry, J Pelham… - 2022 - researchsquare.com
Organismal physiology is widely regulated by the circadian clock, a molecular circuit composed
of a Transcription-Translation Feedback Loop 1, 2. Protein components of the molecular …

Attention-deficit/hyperactivity disorder and risk of substance use disorder: Developmental considerations, potential pathways, and opportunities for research

BSG Molina, WE Pelham Jr - Annual review of clinical …, 2014 - annualreviews.org
Many opportunities to explain attention-deficit/hyperactivity disorder (ADHD)-related risk of
substance use disorder (SUD) remain available for study. We detail these opportunities by …

Behavioral and stimulant treatment of hyperactive children: A therapy study with methylphenidate probes in a within‐subject design

WE Pelham, RW Schnedler… - Journal of Applied …, 1980 - Wiley Online Library
… , this study also represents a replication of the SG O'Leary and Pelham (1978) report. … G.,
& Pelham, WE Behavior therapy and withdrawal of stimulant medication with hyperactive …