Background The skeleton plays a critical structural role in bearing functional loads, and failure
to do so results in fracture. As we evaluate new therapeutics and consider treatments to …

Thrombosis, a pathological hemostatic condition, has become one of the leading causes of
cardiovascular mortalities and morbidities worldwide.[1, 2] The unwanted intravascular blood …

Raman spectroscopic diffuse tomographic imaging has been demonstrated for the first time.
It provides a noninvasive, label-free modality to image the chemical composition of human …

Raman spectroscopy can provide valuable information about bone tissue composition in
studies of bone development, biomechanics, and health. In order to study the Raman spectra of …

Osteoporosis alters bone mass and composition ultimately increasing the fragility of primarily
cancellous skeletal sites; however, effects of osteoporosis on tissue-level mechanical …

The effect of optical clearing with glycerol on the Raman spectra of bone tissue acquired
transcutaneously on right and left tibiae from four mice is studied. Multiple transcutaneous …

Raman scattering provides valuable biochemical and molecular markers for studying bone
tissue composition with use in predicting fracture risk in osteoporosis. Raman tomography …

A noninvasive quality monitoring of tissue-engineered constructs is a required component
of any successful tissue-engineering technique. During a 2-week production period, ex vivo …

We report an effective strategy for direct analysis and two-dimensional (2D) infrared matrix-assisted
laser desorption electrospray ionization (IR-MALDESI) mass spectrometry imaging (…

Polyvinylidene fluoride (PVDF) has been considered as an alternative suture material to
replace polypropylene (PP) due to its superior biocompatibility and mechanical properties, but it …