The transplantation of cells that secrete neuroactive substances with analgesic properties
into the CNS is a novel method that challenges current approaches in treating chronic pain. …

The transcription factor nuclear factor kappa B (NF-κB) is a key regulator of inflammatory
processes in reactive glial cells. We utilized a transgenic mouse model (GFAP-IκBα-dn) where …

Painful sensory neuropathy is a common and debilitating consequence of human
immunodeficiency virus (HIV). The underlying causes of neuropathic pain are most likely not due to …

Purpose: A proliferation of stem/progenitor cells is observed after brain injury. We examined
the regional and temporal profile of mitotically active cells to determine whether traumatic …

Adrenal medullary chromaffin cells are a potential source of neuroactive substances for
transplantation into the CNS to alleviate neurochemical deficits. In particular, work in our …

Spinal cord injury (SCI) produces both locomotor deficits and sensory dysfunction that greatly
reduce the overall quality of life. Mechanisms underlying chronic pain include increased …

The most frequently reported use of medical marijuana is for pain relief. However, its
psychoactive component Δ9-tetrahydrocannabinol (THC) causes significant side effects. …

Symptoms of neuropathic spinal cord injury (SCI) pain include cutaneous hypersensitivity
and spontaneous pain below the level of the injury. Riluzole, an FDA-approved drug for the …

Recent evidence suggests that some groups of noradrenergic neurons found in the brainstem
have axonal connections in the spinal cord dorsal horn and may be involved in the control …

Pre-clinical evidence demonstrates that neuropathic spinal cord injury (SCI) pain is maintained
by a number of neurobiological mechanisms, suggesting that treatments directed at …