Peroxisomes are highly metabolic, autonomously replicating organelles that generate reactive
oxygen species (ROS) as a by-product of fatty acid β-oxidation. Consequently, cells must …

Ataxia-telangiectasia mutated (ATM) plays a central role in DNA damage responses, and its
loss leads to development of T-cell malignancies. Here, we show that ATM loss also leads to …

Subcellular localization is emerging as an important mechanism for mTORC1 regulation.
We report that the tuberous sclerosis complex (TSC) signalling node, TSC1, TSC2 and Rheb, …

Our work highlights an unanticipated role for PSCs in producing the oncogenic LPA
signaling lipid and demonstrates how PDAC tumor cells co-opt the release of wound-healing …

Recruitment of DNA repair factors and modulation of chromatin structure at sites of DNA
double-strand breaks (DSBs) is a complex and highly orchestrated process. We developed a …

Exploiting oxidative stress has recently emerged as a plausible strategy for treatment of
human cancer, and antioxidant defenses are implicated in resistance to chemotherapy and …

Hürthle cell carcinomas (HCCs) display two exceptional genotypes: near-homoplasmic
mutation of mitochondrial DNA (mtDNA) and genome-wide loss of heterozygosity (gLOH). To …

Formate is a precursor for the de novo synthesis of purine and deoxythymidine nucleotides.
Formate also interacts with energy metabolism by promoting the synthesis of adenine …

Pancreatic ductal adenocarcinoma (PDAC) features a near-universal mutation in KRAS.
Additionally, the tumor suppressor PTEN is lost in ∼10% of patients, and in mouse models, this …

The mitochondrial genome (mtDNA) encodes essential machinery for oxidative phosphorylation
and metabolic homeostasis. Tumor mtDNA is among the most somatically mutated …