User profiles for Jacques Fellay
 | Jacques FellayEPFL / CHUV Verified email at epfl.ch Cited by 26191 |
Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance
Chronic infection with hepatitis C virus (HCV) affects 170 million people worldwide and is
the leading cause of cirrhosis in North America 1 . Although the recommended treatment for …
the leading cause of cirrhosis in North America 1 . Although the recommended treatment for …
A whole-genome association study of major determinants for host control of HIV-1
Understanding why some people establish and maintain effective control of HIV-1 and
others do not is a priority in the effort to develop new treatments for HIV/AIDS. Using a whole-…
others do not is a priority in the effort to develop new treatments for HIV/AIDS. Using a whole-…
Inborn errors of type I IFN immunity in patients with life-threatening COVID-19
INTRODUCTION Clinical outcomes of human severe acute respiratory syndrome coronavirus
2 (SARS-CoV-2) infection range from silent infection to lethal coronavirus disease 2019 (…
2 (SARS-CoV-2) infection range from silent infection to lethal coronavirus disease 2019 (…
Interleukin-28B polymorphism improves viral kinetics and is the strongest pretreatment predictor of sustained virologic response in genotype 1 hepatitis C virus
BACKGROUND & AIMS: We recently identified a polymorphism upstream of interleukin (IL)-28B
to be associated with a 2-fold difference in sustained virologic response (SVR) rates to …
to be associated with a 2-fold difference in sustained virologic response (SVR) rates to …
Response to antiretroviral treatment in HIV-1-infected individuals with allelic variants of the multidrug resistance transporter 1: a pharmacogenetics study
Background HIV-1-infected patients vary considerably by their response to antiretroviral
treatment, drug concentrations in plasma, toxic events, and rate of immune recovery. This …
treatment, drug concentrations in plasma, toxic events, and rate of immune recovery. This …
[PDF][PDF] IL28B genotype is associated with differential expression of intrahepatic interferon‐stimulated genes in patients with chronic hepatitis C
Genetic variation in the IL28B (interleukin 28B; interferon lambda 3) region has been
associated with sustained virological response (SVR) rates in patients with chronic hepatitis C (…
associated with sustained virological response (SVR) rates in patients with chronic hepatitis C (…
COVID-19 epidemic in Switzerland: on the importance of testing, contact tracing and isolation
Switzerland is among the countries with the highest number of coronavirus disease-2019 (COVID-19)
cases per capita in the world. There are likely many people with undetected SARS-…
cases per capita in the world. There are likely many people with undetected SARS-…
[HTML][HTML] Common genetic variation and the control of HIV-1 in humans
To extend the understanding of host genetic determinants of HIV-1 control, we performed a
genome-wide association study in a cohort of 2,554 infected Caucasian subjects. The study …
genome-wide association study in a cohort of 2,554 infected Caucasian subjects. The study …
ITPA gene variants protect against anaemia in patients treated for chronic hepatitis C
Chronic infection with the hepatitis C virus (HCV) affects 170 million people worldwide and
is an important cause of liver-related morbidity and mortality 1 . The standard of care therapy …
is an important cause of liver-related morbidity and mortality 1 . The standard of care therapy …
Autoantibodies neutralizing type I IFNs are present in~ 4% of uninfected individuals over 70 years old and account for~ 20% of COVID-19 deaths
…, A Bondarenko, AN Spaan, L Gilardin, J Fellay… - Science …, 2021 - science.org
Circulating autoantibodies (auto-Abs) neutralizing high concentrations (10 ng/ml; in plasma
diluted 1:10) of IFN-α and/or IFN-ω are found in about 10% of patients with critical COVID-19 …
diluted 1:10) of IFN-α and/or IFN-ω are found in about 10% of patients with critical COVID-19 …