… Jacques JC Neefjes Jacques Neefjes got his PhD for studies on antigen presentation by MHC
class I … After a post-doc at the DKFZ in Heidelberg, Neefjes started his group at the NKI in …

Cholesterol import in mammalian cells is mediated by the LDL receptor pathway. Here, we
perform a genome-wide CRISPR screen using an endogenous cholesterol reporter and …

Proteasome inhibitors are established therapeutic agents for the treatment of hematological
cancers, as are anthracyclines such as doxorubicin. We here present a new drug targeting …

Laboratory data increasingly suggest that Salmonella infection may contribute to colon
cancer (CC) development. Here, we examined epidemiologically the potential risk of CC …

Anthracyclines are effective drugs in the treatment of various cancers, but their use comes
with severe side effects. The archetypal anthracycline drug, doxorubicin, displays two …

Malignant pleural mesothelioma is an aggressive fatal malignancy with a prognosis that has
not significantly improved in the last decades. This review summarizes the current state of …

The anthracycline anti-cancer drugs are intensely used in the clinic to treat a wide variety of
cancers. They generate DNA double strand breaks, but recently the induction of chromatin …

Introduction: Daunorubicin and doxorubicin, two anthracycline polyketides produced by S.
peucetius, are potent anticancer agents that are widely used in chemotherapy, despite severe …

Saliva is a complex bodily fluid composed of metabolites secreted by major and minor
glands, as well as by-products of host oral cells, oral bacteria, gingival crevicular fluid, and …

Objectives Occupational exposure to animals and foods thereof is a poorly characterised
risk factor for salmonellosis and campylobacteriosis, the main causes of bacterial …