Genomic variation among contemporary Pseudomonas aeruginosa isolates from chronically infected cystic fibrosis patients

JCS Chung, J Becq, L Fraser… - Journal of …, 2012 - Am Soc Microbiol
… This work was supported in part by a studentship awarded to Jade CS Chung from the
BBSRC and by the Cambridge Newton Trust. We thank Illumina for funding the genome …

Virulence in Pectobacterium atrosepticum is regulated by a coincidence circuit involving quorum sensing and the stress alarmone, (p)ppGpp

SD Bowden, A Eyres, JCS Chung… - Molecular …, 2013 - Wiley Online Library
P ectobacterium atrosepticum ( P ca) is a Gram‐negative phytopathogen which causes
disease by secreting plant cell wall degrading exoenzymes ( PCWDEs ). Previous studies have …

EspT triggers formation of lamellipodia and membrane ruffles through activation of Rac‐1 and Cdc42

RR Bulgin, A Arbeloa, JCS Chung… - Cellular …, 2009 - Wiley Online Library
Subversion of the eukaryotic cell cytoskeleton is a virulence strategy employed by many
bacterial pathogens. Due to the pivotal role of Rho GTPases in actin dynamics they are common …

Type III secretion system expression in oxygen-limited Pseudomonas aeruginosa cultures is stimulated by isocitrate lyase activity

JCS Chung, O Rzhepishevska, M Ramstedt… - Open …, 2013 - royalsocietypublishing.org
Pseudomonas aeruginosa is an opportunistic human pathogen and a common cause of
chronic infections in individuals with cystic fibrosis (CF). Oxygen limitation was recently reported …

Surface swarming motility by Pectobacterium atrosepticum is a latent phenotype that requires O antigen and is regulated by quorum sensing

SD Bowden, N Hale, JCS Chung… - …, 2013 - microbiologyresearch.org
We describe a previously cryptic phenotype associated with the opportunistic phytopathogen
Pectobacterium atrosepticum (Pca): surface swarming. We found that when Pca was …

Mep72, a metzincin protease that is preferentially secreted by biofilms of Pseudomonas aeruginosa

…, KS Lilley, SD Bowden, JCS Chung… - Journal of …, 2015 - Am Soc Microbiol
In this work, we compared the profile of proteins secreted by planktonic and biofilm cultures
of Pseudomonas aeruginosa using two-dimensional difference gel electrophoresis (2D-DiGE…

[HTML][HTML] Developmental transcriptome of resting cell formation in Mycobacterium smegmatis

ML Wu, M Gengenbacher, JCS Chung, SL Chen… - BMC genomics, 2016 - Springer
Background Mycobacteria, along with exospore forming Streptomyces, belong to the phylum
actinobacteria. Mycobacteria are generally believed to be non-differentiating. Recently …

Lacer: accurate base quality score recalibration for improving variant calling from next-generation sequencing data in any organism

JCS Chung, SL Chen - BioRxiv, 2017 - biorxiv.org
Next-generation sequencing data is accompanied by quality scores that quantify sequencing
error. Inaccuracies in these quality scores propagate through all subsequent analyses; thus …

Universal soldier: Pseudomonas aeruginosa — an opportunistic generalist

J Gross, IJ Passmore, JCS Chung, O Rzhepishevska… - Frontiers in biology, 2013 - Springer
The opportunistic pathogen Pseudomonas aeruginosa commonly causes chronic and
ultimately deadly lung infections in individuals with the genetic disease cystic fibrosis (CF). P. …

[PDF][PDF] Type III secretion system expression in oxygen-limited

JCS Chung, O Rzhepishevska… - Pseudomonas …, 2013 - researchgate.net
1. Summary Pseudomonas aeruginosa is an opportunistic human pathogen and a common
cause of chronic infections in individuals with cystic fibrosis (CF). Oxygen limitation was …