The population history of Aboriginal Australians remains largely uncharacterized. Here we
generate high-coverage genomes for 83 Aboriginal Australians (speakers of Pama–Nyungan …

Caveolae are small, bulb-shaped plasma membrane invaginations. Mutations that ablate
caveolae lead to diverse phenotypes in mice and humans, making it challenging to uncover …

The maritime expansion of Scandinavian populations during the Viking Age (about ad 750–1050)
was a far-flung transformation in world history 1, 2. Here we sequenced the genomes …

Understanding the physiology and genetics of human hypoxia tolerance has important
medical implications, but this phenomenon has thus far only been investigated in high-altitude …

Background Genomic studies of endangered species provide insights into their evolution and
demographic history, reveal patterns of genomic erosion that might limit their viability, and …

In the 1950s the myxoma virus was released into European rabbit populations in Australia
and Europe, decimating populations and resulting in the rapid evolution of resistance. We …

Caveolae are strikingly abundant in endothelial cells, yet the physiological functions of
caveolae in endothelium and other tissues remain incompletely understood. Previous studies …

Recent studies suggest that closely related species can accumulate substantial genetic and
phenotypic differences despite ongoing gene flow, thus challenging traditional ideas …

The increase in red blood cell mass (polycythemia) due to the reduced oxygen availability (hypoxia)
of residence at high altitude or other conditions is generally thought to be beneficial …

One of the most powerful and commonly used approaches for detecting local adaptation in
the genome is the identification of extreme allele frequency differences between populations. …