SAMHD1 was previously characterized as a dNTPase that protects cells from viral infections.
Mutations in SAMHD1 are implicated in cancer development and in a severe congenital …

DNA replication stress can cause chromosomal instability and tumor progression. One key
pathway that counteracts replication stress and promotes faithful DNA replication consists of …

SF3B1 hotspot mutations are associated with a poor prognosis in several tumor types and
lead to global disruption of canonical splicing. Through synthetic lethal drug screens, we …

Recognition and repair of damaged replication forks are essential to maintain genome
stability and are coordinated by the combined action of the Fanconi anemia and homologous …

Faithful duplication of genetic material during every cell division is essential to ensure accurate
transmission of genetic information to daughter cells. DNA helicases play a crucial role in …

Defective DNA repair causes Fanconi anemia (FA), a rare childhood cancer–predisposing
syndrome. At least 15 genes are known to be mutated in FA; however, their role in DNA repair …

Repair of DNA double-strand breaks (DSBs) by homologous recombination (HR) is critical
for survival and genome stability of individual cells and organisms, but also contributes to the …

During mitosis, sister chromatids must be faithfully segregated to ensure that daughter cells
receive one copy of each chromosome. However, following replication they often remain …

Background ALKBH proteins, the homologs of Escherichia coli AlkB dioxygenase, constitute
a direct, single-protein repair system, protecting cellular DNA and RNA against the cytotoxic …

FANCM is the most highly conserved protein within the Fanconi anaemia (FA) tumour
suppressor pathway. However, although FANCM contains a helicase domain with translocase …