[HTML][HTML] Heat shock protein 70 inhibits apoptosis downstream of cytochrome c release and upstream of caspase-3 activation
Heat shock protein 70 (HSP70) has been shown to act as an inhibitor of apoptosis. We have
also observed an inhibitory effect of HSP70 on apoptotic cell death both in preheated U937 …
also observed an inhibitory effect of HSP70 on apoptotic cell death both in preheated U937 …
[HTML][HTML] Hsp72 functions as a natural inhibitory protein of c‐Jun N‐terminal kinase
Hsp72, a major inducible member of the heat shock protein family, can protect cells against
many cellular stresses including heat shock. In our present study, we observed that …
many cellular stresses including heat shock. In our present study, we observed that …
Dissecting the role of Rho-mediated signaling in contractile ring formation
…, M Abe, T Uchimura, H Hosoya, JS Lee… - Molecular biology of …, 2006 - Am Soc Cell Biol
In anaphase, microtubules provide a specification signal for positioning of the contractile
ring. However, the nature of the signal remains unknown. The small GTPase Rho is a potent …
ring. However, the nature of the signal remains unknown. The small GTPase Rho is a potent …
[HTML][HTML] A spindle checkpoint arrest and a cytokinesis failure by the dominant-negative Polo-box domain of Plk1 in U-2 OS Cells* 210
YS Seong, K Kamijo, JS Lee, E Fernandez… - Journal of Biological …, 2002 - ASBMB
Polo kinases play critical roles for proper M-phase progression. They are characterized by
the presence of two regions of homology in the C-terminal non-catalytic domain, termed polo-…
the presence of two regions of homology in the C-terminal non-catalytic domain, termed polo-…
Heat shock protein hsp72 is a negative regulator of apoptosis signal-regulating kinase 1
…, K Ryoo, EK Kim, WJ Kang, JS Lee… - … and cellular biology, 2002 - Taylor & Francis
Heat shock protein 72 (Hsp72) is thought to protect cells against cellular stress. The protective
role of Hsp72 was investigated by determining the effect of this protein on the stress-…
role of Hsp72 was investigated by determining the effect of this protein on the stress-…
[HTML][HTML] MG53-induced IRS-1 ubiquitination negatively regulates skeletal myogenesis and insulin signalling
Mitsugumin 53 (MG53) negatively regulates skeletal myogenesis by targeting insulin receptor
substrate 1 (IRS-1). Here, we show that MG53 is an ubiquitin E3 ligase that induces IRS-1 …
substrate 1 (IRS-1). Here, we show that MG53 is an ubiquitin E3 ligase that induces IRS-1 …
Targeted hsp70.1 Disruption Increases Infarction Volume After Focal Cerebral Ischemia in Mice
Background and Purpose— Heat-shock proteins (HSPs) are highly conserved proteins that
are induced by a variety of stresses. HSP70 is a 70-kDa HSP family known to have …
are induced by a variety of stresses. HSP70 is a 70-kDa HSP family known to have …
Sialylation of epidermal growth factor receptor regulates receptor activity and chemosensitivity to gefitinib in colon cancer cells
β-Galactoside α2,6-sialyltransferase (ST6Gal-I) has been shown to catalyze α2,6 sialylation
of N-glycan, an action that is highly correlated with colon cancer progression and metastasis…
of N-glycan, an action that is highly correlated with colon cancer progression and metastasis…
[HTML][HTML] NQO1 inhibits proteasome-mediated degradation of HIF-1α
…, RJ Ruthenborg, MG Jung, HJ Lee, CH Lee… - Nature …, 2016 - nature.com
Overexpression of NQO1 is associated with poor prognosis in human cancers including
breast, colon, cervix, lung and pancreas. Yet, the molecular mechanisms underlying the pro-…
breast, colon, cervix, lung and pancreas. Yet, the molecular mechanisms underlying the pro-…
Fibronectin regulates anoikis resistance via cell aggregate formation
…, EJ Jang, HE Yoo, EK Hong, SH Goh, A Moon, JS Lee… - Cancer letters, 2021 - Elsevier
The loss of cell-matrix interactions induces apoptosis, known as anoikis. For successful
distant metastasis, circulating tumor cells (CTCs) that have lost matrix attachment need to …
distant metastasis, circulating tumor cells (CTCs) that have lost matrix attachment need to …