Older concepts of a hard-wired adult brain have been overturned in recent years by in vivo
imaging studies revealing synaptic remodeling, now thought to mediate rearrangements in …

Synapse loss is the strongest correlate for cognitive decline in Alzheimer's disease. The
mechanisms underlying synapse loss have been extensively investigated using mouse models …

Neuronal hyperactivity induces memory deficits in Alzheimer's disease. However, how
hyperactivity disrupts memory is unclear. Using in vivo synaptic imaging in the mouse visual cortex…

A key feature of brain plasticity is the experience-dependent selection of optimal connections,
implemented by a set of activity-regulated genes that dynamically adjust synapse strength …

The small GTPase Rap1 contributes to fear learning and cortico-amygdala plasticity by
inhibiting glutamate release from cortical neurons, but mechanisms of this inhibition remain …

Alzheimer's disease patients and mouse models exhibit aberrant neuronal activity and
altered excitatory-to-inhibitory synaptic ratio. Using multicolor two-photon microscopy, we test …

Recombination and microsatellite mutation in humans contribute to disorders including cancer
and trinucleotide repeat (TNR) disease. TNR expansions in wild-type yeast may arise by …

L-type calcium channels play only a minor role in basal neurotransmitter release in brain
neurons but contribute significantly after induction of plasticity. Very little is known about …

During development, experience plays a crucial role in sculpting neuronal connections.
Patterned neural activity guides formation of functional neural circuits through the selective …

Multifocal multiphoton microscopy (MMM) achieves fast imaging by simultaneously scanning
multiple foci across different regions of specimen. The use of imaging detectors in MMM, …