[HTML][HTML] SARS-CoV-2 infection of African green monkeys results in mild respiratory disease discernible by PET/CT imaging and shedding of infectious virus from both …
…, EL Olsen, KJ O'Malley, MM Schwarz, JA Tomko… - PLoS …, 2020 - journals.plos.org
Vaccines are urgently needed to combat the global coronavirus disease 2019 (COVID-19)
pandemic, and testing of candidate vaccines in an appropriate non-human primate (NHP) …
pandemic, and testing of candidate vaccines in an appropriate non-human primate (NHP) …
[PDF][PDF] Multimodal profiling of lung granulomas in macaques reveals cellular correlates of tuberculosis control
…, CL Ameel, CT Cochran, S Ibrahim, JA Tomko… - Immunity, 2022 - cell.com
Mycobacterium tuberculosis lung infection results in a complex multicellular structure: the
granuloma. In some granulomas, immune activity promotes bacterial clearance, but in others, …
granuloma. In some granulomas, immune activity promotes bacterial clearance, but in others, …
Radiologic responses in cynomolgus macaques for assessing tuberculosis chemotherapy regimens
…, JPJ Carney, BJ Lopresti, J Tomko… - Antimicrobial agents …, 2013 - Am Soc Microbiol
Trials to test new drugs currently in development against tuberculosis in humans are
impractical. All animal models to prioritize new regimens are imperfect, but nonhuman primates (…
impractical. All animal models to prioritize new regimens are imperfect, but nonhuman primates (…
Airway T cells are a correlate of iv Bacille Calmette-Guerin-mediated protection against tuberculosis in rhesus macaques
Bacille Calmette-Guerin (BCG), the only approved Mycobacterium tuberculosis (Mtb) vaccine,
provides limited durable protection when administered intradermally. However, recent …
provides limited durable protection when administered intradermally. However, recent …
Early Changes by 18Fluorodeoxyglucose Positron Emission Tomography Coregistered with Computed Tomography Predict Outcome after Mycobacterium …
MT Coleman, P Maiello, J Tomko, LJ Frye… - Infection and …, 2014 - Am Soc Microbiol
Cynomolgus macaques infected with low-dose Mycobacterium tuberculosis develop both
active tuberculosis and latent infection similar to those of humans, providing an opportunity to …
active tuberculosis and latent infection similar to those of humans, providing an opportunity to …
Differential virulence and disease progression following Mycobacterium tuberculosis complex infection of the common marmoset (Callithrix jacchus)
…, Y Cai, MT Coleman, J Tomko… - Infection and …, 2013 - Am Soc Microbiol
Existing small-animal models of tuberculosis (TB) rarely develop cavitary disease, limiting
their value for assessing the biology and dynamics of this highly important feature of human …
their value for assessing the biology and dynamics of this highly important feature of human …
[HTML][HTML] PET CT Identifies Reactivation Risk in Cynomolgus Macaques with Latent M. tuberculosis
…, MA Rodgers, R Gregg, M O'Malley, J Tomko… - PLoS …, 2016 - journals.plos.org
Mycobacterium tuberculosis infection presents across a spectrum in humans, from latent
infection to active tuberculosis. Among those with latent tuberculosis, it is now recognized that …
infection to active tuberculosis. Among those with latent tuberculosis, it is now recognized that …
CD8+ lymphocytes are critical for early control of tuberculosis in macaques
…, T Hughes, RJ Kelly, J Griffo, J Tomko… - Journal of Experimental …, 2023 - rupress.org
The functional role of CD8 + lymphocytes in tuberculosis remains poorly understood. We
depleted innate and/or adaptive CD8 + lymphocytes in macaques and showed that loss of all …
depleted innate and/or adaptive CD8 + lymphocytes in macaques and showed that loss of all …
[HTML][HTML] Intravenous Bacille Calmette–Guérin vaccination protects simian immunodeficiency virus-infected macaques from tuberculosis
…, AJ Balgeman, CL Ameel, S Jauro, JA Tomko… - Nature …, 2023 - nature.com
Tuberculosis, caused by Mycobacterium tuberculosis (Mtb), is the most common cause of
death in people living with human immunodeficiency virus (HIV). Intra-dermal Bacille Calmette–…
death in people living with human immunodeficiency virus (HIV). Intra-dermal Bacille Calmette–…
Analysis of 18FDG PET/CT imaging as a tool for studying Mycobacterium tuberculosis infection and treatment in non-human primates
AG White, P Maiello, MT Coleman, JA Tomko… - JoVE (Journal of …, 2017 - jove.com
Mycobacterium tuberculosis remains the number one infectious agent in the world today.
With the emergence of antibiotic resistant strains, new clinically relevant methods are needed …
With the emergence of antibiotic resistant strains, new clinically relevant methods are needed …