User profiles for Jake M. Cashion

Jake M. Cashion

University of Tasmania
Verified email at utas.edu.au
Cited by 34

[HTML][HTML] How does neurovascular unit dysfunction contribute to multiple sclerosis?

JM Cashion, KM Young, BA Sutherland - Neurobiology of Disease, 2023 - Elsevier
Multiple sclerosis is an inflammatory demyelinating disease of the central nervous system (CNS)
and the most common non-traumatic cause of neurological disability in young adults. …

Microglia directly associate with pericytes in the central nervous system

…, CG Foster, JM Courtney, JM Collins, JM Cashion… - Glia, 2023 - Wiley Online Library
Cerebral blood flow (CBF) is important for the maintenance of brain function and its
dysregulation has been implicated in Alzheimer's disease (AD). Microglia associations with …

Pharmacological PDGFRβ inhibitors imatinib and sunitinib cause human brain pericyte death in vitro

…, LS Brown, CG Foster, JM Cashion… - Toxicology and Applied …, 2022 - Elsevier
Capillary pericytes have numerous functions important for tissue maintenance. Changes in
pericyte function are implicated in diseases such as cancer, where pericyte-mediated …

[HTML][HTML] Induced pluripotent stem cell derived pericytes respond to mediators of proliferation and contractility

…, JL Fletcher, JM Cashion… - … Cell Research & …, 2024 - stemcellres.biomedcentral.com
Pericytes are multifunctional contractile cells that reside on capillaries. Pericytes are critical
regulators of cerebral blood flow and blood–brain barrier function, and pericyte dysfunction …

Microglia associations with brain pericytes and the vasculature are reduced in Alzheimer's disease

…, CG Foster, JM Courtney, JM Collins, JM Cashion… - bioRxiv, 2022 - biorxiv.org
Cerebral blood flow is important for the maintenance of brain function and its dysregulation
has been implicated in Alzheimer’s disease (AD). Subpopulations of microglia have well-…

Pericyte ablation causes hypoactivity and reactive gliosis in adult mice

JM Cashion, LS Brown, GP Morris, AJ Fortune… - bioRxiv, 2023 - biorxiv.org
Pericytes are contractile cells that enwrap capillaries allowing them to control blood flow,
maintain the blood-brain barrier and regulate immune cell trafficking in the CNS. Pericytes are …

Induced pluripotent stem cell derived pericytes respond to endogenous mediators of proliferation and contractility

…, AJ Fortune, NB Blackburn, JL Fletcher, JM Cashion… - bioRxiv, 2023 - biorxiv.org
Pericytes are multifunctional contractile cells that reside on capillaries. Pericytes are critical
regulators of cerebral blood flow and blood-brain barrier function, and pericyte dysfunction …

H3K4me3 enrichment defines neuronal age, while a youthful H3K27ac signature is recapitulated in aged neurons

KA Giles, AJ Phipps, JM Cashion, SN Huskins… - bioRxiv, 2021 - biorxiv.org
Neurons live for the lifespan of the individual and underlie our ability for lifelong learning
and memory. However, aging alters neuron morphology and function resulting in age-related …

The role of capillary and pericyte associated microglia in health and Alzheimer's disease

…, JM Courtney, JM Collins, JM Cashion… - Alzheimer's & …, 2023 - Wiley Online Library
Background The majority of individuals with Alzheimer’s disease (AD) exhibit vascular
damage in the brain including reduced cerebral blood flow (CBF) and blood‐brain‐barrier (BBB) …

[CITATION][C] Cover Image, Volume 71, Issue 8

…, CG Foster, JM Courtney, JM Collins, JM Cashion… - Glia, 2023 - Wiley Online Library
Cover Illustration: 3D reconstruction derived from transmission electron microscope images
from the MICrONS Cortical-mm3 dataset (https://www. microns-explorer. org/cortical-mm3) of …