User profiles for Jake M. Cashion
Jake M. CashionUniversity of Tasmania Verified email at utas.edu.au Cited by 34 |
[HTML][HTML] How does neurovascular unit dysfunction contribute to multiple sclerosis?
Multiple sclerosis is an inflammatory demyelinating disease of the central nervous system (CNS)
and the most common non-traumatic cause of neurological disability in young adults. …
and the most common non-traumatic cause of neurological disability in young adults. …
Microglia directly associate with pericytes in the central nervous system
Cerebral blood flow (CBF) is important for the maintenance of brain function and its
dysregulation has been implicated in Alzheimer's disease (AD). Microglia associations with …
dysregulation has been implicated in Alzheimer's disease (AD). Microglia associations with …
Pharmacological PDGFRβ inhibitors imatinib and sunitinib cause human brain pericyte death in vitro
Capillary pericytes have numerous functions important for tissue maintenance. Changes in
pericyte function are implicated in diseases such as cancer, where pericyte-mediated …
pericyte function are implicated in diseases such as cancer, where pericyte-mediated …
[HTML][HTML] Induced pluripotent stem cell derived pericytes respond to mediators of proliferation and contractility
…, JL Fletcher, JM Cashion… - … Cell Research & …, 2024 - stemcellres.biomedcentral.com
Pericytes are multifunctional contractile cells that reside on capillaries. Pericytes are critical
regulators of cerebral blood flow and blood–brain barrier function, and pericyte dysfunction …
regulators of cerebral blood flow and blood–brain barrier function, and pericyte dysfunction …
Microglia associations with brain pericytes and the vasculature are reduced in Alzheimer's disease
Cerebral blood flow is important for the maintenance of brain function and its dysregulation
has been implicated in Alzheimer’s disease (AD). Subpopulations of microglia have well-…
has been implicated in Alzheimer’s disease (AD). Subpopulations of microglia have well-…
Pericyte ablation causes hypoactivity and reactive gliosis in adult mice
Pericytes are contractile cells that enwrap capillaries allowing them to control blood flow,
maintain the blood-brain barrier and regulate immune cell trafficking in the CNS. Pericytes are …
maintain the blood-brain barrier and regulate immune cell trafficking in the CNS. Pericytes are …
Induced pluripotent stem cell derived pericytes respond to endogenous mediators of proliferation and contractility
Pericytes are multifunctional contractile cells that reside on capillaries. Pericytes are critical
regulators of cerebral blood flow and blood-brain barrier function, and pericyte dysfunction …
regulators of cerebral blood flow and blood-brain barrier function, and pericyte dysfunction …
H3K4me3 enrichment defines neuronal age, while a youthful H3K27ac signature is recapitulated in aged neurons
Neurons live for the lifespan of the individual and underlie our ability for lifelong learning
and memory. However, aging alters neuron morphology and function resulting in age-related …
and memory. However, aging alters neuron morphology and function resulting in age-related …
The role of capillary and pericyte associated microglia in health and Alzheimer's disease
…, JM Courtney, JM Collins, JM Cashion… - Alzheimer's & …, 2023 - Wiley Online Library
Background The majority of individuals with Alzheimer’s disease (AD) exhibit vascular
damage in the brain including reduced cerebral blood flow (CBF) and blood‐brain‐barrier (BBB) …
damage in the brain including reduced cerebral blood flow (CBF) and blood‐brain‐barrier (BBB) …
[CITATION][C] Cover Image, Volume 71, Issue 8
Cover Illustration: 3D reconstruction derived from transmission electron microscope images
from the MICrONS Cortical-mm3 dataset (https://www. microns-explorer. org/cortical-mm3) of …
from the MICrONS Cortical-mm3 dataset (https://www. microns-explorer. org/cortical-mm3) of …