Aneuploidy, an incorrect chromosome number, is a hallmark of cancer. Compounds that cause
lethality in aneuploid, but not euploid, cells could therefore provide new cancer therapies. …

Deviation from a balanced genome by either gain or loss of entire chromosomes is generally
tolerated poorly in all eukaryotic systems studied to date. Errors in mitotic or meiotic cell …

The Nuclear Pore Complex (NPC) is the selective filter that facilitates all exchange between
the cytoplasm and the nucleus in eukaryotic cells, allowing small molecules to passively …

10.7554/eLife.35471.001 Heritable variation in gene expression forms a crucial bridge between
genomic variation and the biology of many traits. However, most expression quantitative …

Understanding the functional effects of DNA sequence variants is of critical importance for
studies of basic biology, evolution, and medical genetics; however, measuring these effects in …

Abstract Knowledge of the mechanical properties of double-stranded DNA (dsDNA) is essential
to understand the role of dsDNA looping in gene regulation and the mechanochemistry …

Aneuploidy, an incorrect chromosome number, is a hallmark of cancer. Compounds that cause
lethality in aneuploid but not euploid cells could therefore provide new cancer therapies. …

Direct measurement of functional effects of DNA sequence variants throughout a genome is
a major challenge. We developed a method that uses CRISPR/Cas9 to engineer many …

Within the channel, cargos move in a non-directional manner, consistent with anomalous
subdiffusion in a crowded volume, with dimensions of~ 55 nm in width and~ 68 nm in length. …

The shift toward condition-based monitoring is a key area of research for many military,
industrial, and commercial customers who want to lower the overall operating costs of capital …