User profiles for Jakob Wirbel
Jakob WirbelPostdoctoral Fellow, Stanford School of Medicine Verified email at stanford.edu Cited by 2665 |
Meta-analysis of fecal metagenomes reveals global microbial signatures that are specific for colorectal cancer
Association studies have linked microbiome alterations with many human diseases.
However, they have not always reported consistent results, thereby necessitating cross-study …
However, they have not always reported consistent results, thereby necessitating cross-study …
[HTML][HTML] Microbiome meta-analysis and cross-disease comparison enabled by the SIAMCAT machine learning toolbox
The human microbiome is increasingly mined for diagnostic and therapeutic biomarkers
using machine learning (ML). However, metagenomics-specific software is scarce, and …
using machine learning (ML). However, metagenomics-specific software is scarce, and …
Metagenomic analysis of colorectal cancer datasets identifies cross-cohort microbial diagnostic signatures and a link with choline degradation
Several studies have investigated links between the gut microbiome and colorectal cancer (CRC),
but questions remain about the replicability of biomarkers across cohorts and …
but questions remain about the replicability of biomarkers across cohorts and …
Unravelling the collateral damage of antibiotics on gut bacteria
Antibiotics are used to fight pathogens but also target commensal bacteria, disturbing the
composition of gut microbiota and causing dysbiosis and disease 1 . Despite this well-known …
composition of gut microbiota and causing dysbiosis and disease 1 . Despite this well-known …
[HTML][HTML] A faecal microbiota signature with high specificity for pancreatic cancer
Background Recent evidence suggests a role for the microbiome in pancreatic ductal
adenocarcinoma (PDAC) aetiology and progression. Objective To explore the faecal and salivary …
adenocarcinoma (PDAC) aetiology and progression. Objective To explore the faecal and salivary …
Extensive transmission of microbes along the gastrointestinal tract
10.7554/eLife.42693.001 The gastrointestinal tract is abundantly colonized by microbes, yet
the translocation of oral species to the intestine is considered a rare aberrant event, and a …
the translocation of oral species to the intestine is considered a rare aberrant event, and a …
[PDF][PDF] Commensal Clostridiales strains mediate effective anti-cancer immune response against solid tumors
…, E Katkeviciute, P Busenhart, A Bircher, J Wirbel… - Cell host & …, 2021 - cell.com
Despite overall success, T cell checkpoint inhibitors for cancer treatment are still only efficient
in a minority of patients. Recently, intestinal microbiota was found to critically modulate anti-…
in a minority of patients. Recently, intestinal microbiota was found to critically modulate anti-…
[HTML][HTML] Cultivation-independent genomes greatly expand taxonomic-profiling capabilities of mOTUs across various environments
Background Taxonomic profiling is a fundamental task in microbiome research that aims to
detect and quantify the relative abundance of microorganisms in biological samples. …
detect and quantify the relative abundance of microorganisms in biological samples. …
[HTML][HTML] Identifying temporal and spatial patterns of variation from multimodal data using MEFISTO
Factor analysis is a widely used method for dimensionality reduction in genome biology, with
applications from personalized health to single-cell biology. Existing factor analysis models …
applications from personalized health to single-cell biology. Existing factor analysis models …
[HTML][HTML] Depression and fatigue in active IBD from a microbiome perspective—a Bayesian approach to faecal metagenomics
AK Thomann, T Wüstenberg, J Wirbel, LL Knoedler… - BMC medicine, 2022 - Springer
Background Extraintestinal symptoms are common in inflammatory bowel diseases (IBD)
and include depression and fatigue. These are highly prevalent especially in active disease, …
and include depression and fatigue. These are highly prevalent especially in active disease, …