Phenotypic bistability in Escherichia coli's central carbon metabolism

O Kotte, B Volkmer, JL Radzikowski… - Molecular systems …, 2014 - embopress.org
Fluctuations in intracellular molecule abundance can lead to distinct, coexisting phenotypes
in isogenic populations. Although metabolism continuously adapts to unpredictable …

The chemical kitchen: toward remote delivery of an interdisciplinary practical course

JL Radzikowski, LC Delmas, AC Spivey… - Journal of Chemical …, 2021 - ACS Publications
This commentary responds to the Covid-19 pandemic which poses a serious challenge for
the delivery of “wet laboratory” practical education. We discuss the “Chemical Kitchen” project…

A Robust Method for Generating, Quantifying, and Testing Large Numbers of Escherichia coli Persisters

SR Vedelaar, JL Radzikowski… - … Persistence: Methods and …, 2021 - Springer
Bacteria can exhibit phenotypes that render them tolerant against antibiotics. However, often
only a few cells of a bacterial population show the so-called persister phenotype, which …

A robust method for generating, quantifying and testing large amounts of Escherichia coli persisters

SR Vedelaar, JL Radzikowski, M Heinemann - bioRxiv, 2020 - biorxiv.org
Bacteria can exhibit phenotypes, which makes them tolerant against antibiotics. However,
often only a few cells of a bacterial population show such so-called persister phenotype, which …

Bacterial persistence is an active σS stress response to metabolic flux limitation

JL Radzikowski, S Vedelaar, D Siegel… - Molecular systems …, 2016 - embopress.org
While persisters are a health threat due to their transient antibiotic tolerance, little is known
about their phenotype and what actually causes persistence. Using a new method for …

Bacterial persistence from a system-level perspective

JL Radzikowski, H Schramke, M Heinemann - Current Opinion in …, 2017 - Elsevier
Highlights • Persister cells are metabolically active and have a phenotype adapted to stress
protection. • Perturbations of metabolic homeostasis might be the common, basic process …

[HTML][HTML] Mutations in respiratory complex I promote antibiotic persistence through alterations in intracellular acidity and protein synthesis

…, JE Michiels, TEP Kimkes, JL Radzikowski… - Nature …, 2022 - nature.com
Antibiotic persistence describes the presence of phenotypic variants within an isogenic bacterial
population that are transiently tolerant to antibiotic treatment. Perturbations of metabolic …

Bacterial Persistence

N Verstraeten, J Michiels - Springer
At the time of this writing, we are in the midst of a global pandemic that presents unprecedented
challenges to health systems. Countless lives are lost, and the economic, social, and …

Systems biology of bacterial persistence, a metabolism-driven strategy for survival

J Radzikowski - 2017 - research.rug.nl
… biology of bacterial persistence, a metabolism-driven strategy for survival Radzikowski,
Jakub … of bacterial persistence, a metabolism-driven strategy for survival Radzikowski, Jakub

[HTML][HTML] Analysis of gastrointestinal acoustic activity using deep neural networks

J Ficek, K Radzikowski, JK Nowak, O Yoshie… - Sensors, 2021 - mdpi.com
Automated bowel sound (BS) analysis methods were already well developed by the early
2000s. Accuracy of ~90% had been achieved by several teams using various analytical …