Background— The delivery of autologous cells to increase angiogenesis is emerging as a
treatment option for patients with cardiovascular disease but may be limited by the …

Background— Endothelial progenitor cells (EPCs) have been isolated from peripheral blood
and can enhance angiogenesis after infusion into host animals. It is not known whether the …

Mitochondria exist in dynamic networks that undergo fusion and fission. Mitochondrial fusion
and fission are mediated by several GTPases in the outer mitochondrial membrane, notably …

Increasing evidence recognizes Alzheimer's disease (AD) as a multifactorial and heterogeneous
disease with multiple contributors to its pathophysiology, including vascular dysfunction…

Abnormal tumor vessels promote metastasis and impair chemotherapy. Hence, tumor vessel
normalization (TVN) is emerging as an anti-cancer treatment. Here, we show that tumor …

Rationale: Pulmonary arterial hypertension (PAH) is a lethal syndrome characterized by
pulmonary vascular obstruction caused, in part, by pulmonary artery smooth muscle cell (…

Background— Excessive proliferation and impaired apoptosis of pulmonary artery (PA)
smooth muscle cells (PASMCs) contribute to vascular obstruction in patients and fawn-hooded …

Objectives : We investigated whether a single episode of exercise could acutely increase the
numbers of endothelial progenitor cells (EPCs) and cultured/circulating angiogenic cells (…

Acute lung injury is a leading cause of death in bacterial sepsis due to the wholesale
destruction of the lung endothelial barrier, which results in protein-rich lung edema, influx of …

Right ventricular hypertrophy (RVH) and RV failure contribute to morbidity and mortality in
pulmonary arterial hypertension (PAH). The cause of RV dysfunction and the feasibility of …