The bis-indole indirubin is an active ingredient of Danggui Longhui Wan, a traditional
Chinese medicine recipe used in the treatment of chronic diseases such as leukemias. The …

The protein kinase C (PKC) family of serine/threonine kinases functions downstream of
nearly all membrane-associated signal transduction pathways. Here we identify PKC-α as a …

The physiological state of the cell is controlled by signal transduction mechanisms which
regulate the balance between protein kinase and protein phosphatase activities 1 . Here we …

Cocaine enhances dopamine-mediated neurotransmission by blocking dopamine re-uptake
at axon terminals. Most dopamine-containing nerve terminals innervate medium spiny …

Paullones constitute a new family of benzazepinones with promising antitumoral properties.
They were recently described as potent, ATP‐competitive, inhibitors of the cell cycle …

Learning is accompanied by modulation of postsynaptic signal transduction pathways in
neurons. Although the neuronal protein kinase cyclin-dependent kinase 5 (Cdk5) has been …

Melanin-concentrating hormone (MCH) is a hypothalamic neuropeptide with a prominent
role in feeding and energy homeostasis. The rodent MCH receptor (MCH1R) is highly …

NMDA receptor (NMDAR)-mediated excitotoxicity plays an important role in several CNS
disorders, including epilepsy, stroke, and ischemia. Here we demonstrate the involvement of …

In Huntington's disease (HD), mutation of huntingtin causes selective neurodegeneration of
dopaminoceptive striatal medium spiny neurons. Transgenic HD model mice that express a …

Dopamine and cAMP-regulated phosphoprotein of M r 32,000 (DARPP-32) plays an
obligatory role in most of the actions of dopamine. In resting neostriatal slices, cyclin-dependent …