Ferroptosis is a form of regulated cell death that is caused by the iron-dependent peroxidation
of lipids 1 , 2 . The glutathione-dependent lipid hydroperoxidase glutathione peroxidase 4 (…

Lipid droplets are storage organelles at the centre of lipid and energy homeostasis. They have
a unique architecture consisting of a hydrophobic core of neutral lipids, which is enclosed …

Mutations in the PTEN induced putative kinase 1 (PINK1) gene cause an autosomal recessive
form of Parkinson disease (PD). So far, no substrates of PINK1 have been reported, and …

The current study examines the association between glucose induction of reactive oxygen
species (ROS), mitochondrial (Mt) depolarization, and programmed cell death in primary …

The initiation and execution of cell death can be regulated by various lipids. How the levels
of environmental (exogenous) lipids impact cell death sensitivity is not well understood. We …

Mutations in DJ-1 cause an autosomal recessive, early onset familial form of Parkinson
disease (PD). However, little is presently known about the role of DJ-1 in the more common …

Proteins that fail to correctly fold or assemble into oligomeric complexes in the endoplasmic
reticulum (ER) are degraded by a ubiquitin- and proteasome-dependent process known as …

Lipid droplets (LDs) provide an "on-demand" source of fatty acids (FAs) that can be
mobilized in response to fluctuations in nutrient abundance. Surprisingly, the amount of LDs …

Sequestration of misfolded proteins into pericentriolar inclusions called aggresomes is a
means that cells use to minimize misfolded protein-induced cytotoxicity. However, the …

The endoplasmic reticulum (ER) is the site of synthesis for nearly one-third of the eukaryotic
proteome and is accordingly endowed with specialized machinery to ensure that proteins …