[HTML][HTML] Efferocytic defects in early atherosclerosis are driven by GATA2 overexpression in macrophages

C Yin, AM Vrieze, M Rosoga, J Akingbasote… - Frontiers in …, 2020 - frontiersin.org
The loss of efferocytosis—the phagocytic clearance of apoptotic cells—is an initiating event
in atherosclerotic plaque formation. While the loss of macrophage efferocytosis is a …

Toxicological evaluation of a pumpkin-derived pectin preparation: in vitro genotoxicity studies and a 13-week oral toxicity study in Sprague-Dawley rats

AF Kleijn, M Mutter, JA Akingbasote… - Toxicology …, 2024 - academic.oup.com
The safety of a rhamnogalacturonan-I-enriched pectin extract (G3P-01) from pumpkin (Cucurbita
moschata var. Dickinson) was evaluated for use as an ingredient in food and dietary …

[HTML][HTML] The effect of HLA-DRB1* 04: 01 on a mouse model of atherosclerosis

G Blackler, J Akingbasote, E Cairns, C Howlett… - Journal of Translational …, 2023 - Elsevier
Objectives HLA-DRB1 is associated with an increased risk of cardiovascular disease in patients
with rheumatoid arthritis (RA). This study aimed to determine the effect of HLA-DRB1 on …

[PDF][PDF] Huso husoAcute and subacute toxicity study of ethanolic extract of the stem bark of Faidherbia albida (DEL) A. chev (Mimosoidae) in rats

…, TY Adeniyi, JA Akingbasote… - African journal of …, 2010 - ajol.info
… Adeniyi1, James A. Akingbasote1* and Oga E. Florence2 … Tijani AY, Uguru MO,
Salawu OA, Abubakar A, Onyekwelu NO, Akingbasote JA (2009). Effect of Faidherbia albida …

[PDF][PDF] Acute and sub-acute toxicological evaluation of the methanolic stem bark extract of Crossopteryx febrifuga in rats

…, IC Obidike, TA Salawu, AJ Akingbasote - Afr. J. Pharm. and …, 2009 - Citeseer
Crossopteryx febrifuga (Afzel.) Benth.(Rubiaceae) widely used in Northern Nigeria for
management of trypanosomiasis, malaria and pain, has been previously shown to possess …

Safety of cannabis-and hemp-derived constituents in reproduction and development

J Akingbasote, S Szlapinski, A Charrette… - Reproductive and …, 2022 - Elsevier
The global demand for innovative consumer products containing cannabis- and hemp-derived
constituents has placed safety at the forefront of consumers, retailers, and regulatory …

Hepatic effects of repeated oral administration of diclofenac to hepatic cytochrome P450 reductase null (HRN™) and wild-type mice

JA Akingbasote, AJ Foster, I Wilson, S Sarda… - Archives of …, 2016 - Springer
Hepatic NADPH-cytochrome P450 oxidoreductase null (HRN™) mice exhibit normal
hepatic and extrahepatic biotransformation enzyme activities when compared to wild-type (WT) …

Improved hepatic physiology in hepatic cytochrome P450 reductase null (HRN™) mice dosed orally with fenclozic acid

JA Akingbasote, AJ Foster, HB Jones… - Toxicology …, 2017 - academic.oup.com
Hepatic NADPH-cytochrome P450 oxidoreductase null (HRN™) mice exhibit no functional
expression of hepatic cytochrome P450 (P450) when compared to wild type (WT) mice, but …

Cannabidiol safety

A Charrette, J Akingbasote, N Guthrie, CJ Hilmas - Nutraceuticals, 2021 - Elsevier
Cannabidiol (CBD), a naturally occurring constituent compound isolated from cannabis and
hemp, has been the subject of basic science research since 1940. Over the past 5 years, …

Therapeutic Drug Monitoring and Toxicology: Relevance of Measuring Metabolites

J Akingbasote, S Szlapinski, E Hilmas, P Miller… - Recent Advances in …, 2022 - Springer
Therapeutic drug monitoring (TDM) is a valuable tool that healthcare providers have
employed to optimize therapeutic efficacy of drugs while also maintaining drug concentrations …