Hyperpolarization-activated cyclic nucleotide-gated ion channels (h-channels; I h ; HCN)
modulate intrinsic excitability in hippocampal and neocortical pyramidal neurons, among others…

The onset of spontaneous seizures in the pilocarpine model of epilepsy causes a hyperpolarized
shift in the voltage-dependent activation of hyperpolarization-activated cyclic nucleotide…

CBA/Ca male mice have been exposed to benzene in air at 10, 25, 100, 300, 400, and 3000
ppm for variable intervals 6 hr/day, 5 days/week for up to 16 weeks. Two weeks of inhaling …

10.7554/eLife.13503.001 There is a continuing need for driver strains to enable cell-type-specific
manipulation in the nervous system. Each cell type expresses a unique set of genes, …

Retinoic acid-related orphan receptor beta (RORβ) is a transcription factor (TF) and marker
of layer 4 (L4) neurons, which are distinctive both in transcriptional identity and the ability to …

In CA1 and neocortical pyramidal neurons, I h is present primarily in the dendrites. We asked
if all neurons of a pyramidal morphology have a similar density of I h . We characterized a …

In an effort to identify the precise role of a deletion at regions DE of mouse chromosome 2 [del2(DE)]
during the development of radiation-induced myeloid leukemia, we conducted a …

Coding of reaching in the cerebral cortex is based on the operation of distributed populations
of parietal and frontal neurons, whose main functional characteristics reside in their …

AZT has induced a macrocytic anemia in AIDS patients on long term AZT therapy. It is generally
assumed that DNA elongation is stopped by the insertion of AZT into the chain in place …

CBA/Ca male mice were given 3′-azido-3′-deoxythymidine (AZT) in drinking water (1 mg/ml)
for up to 7 weeks. Water consumption and body weight decreased significantly. …