There is an unmet medical need for anabolic treatments to restore lost bone. Human genetic
bone disorders provide insight into bone regulatory processes. Sclerosteosis is a disease …

The recurrent zoonotic spillover of coronaviruses (CoVs) into the human population
underscores the need for broadly active countermeasures. We employed a directed evolution …

A comprehensive understanding of the kinetics and evolution of the human B cell response
to SARS-CoV-2 infection will facilitate the development of next-generation vaccines and …

A null mutation in the SOST gene is associated with sclerosteosis, an inherited disorder
characterized by a high bone mass phenotype. The protein product of the SOST gene, sclerostin…

Infectious prions containing the pathogenic conformer of the mammalian prion protein (PrP
Sc ) can be produced de novo from a mixture of the normal conformer (PrP C ) with RNA and …

Little is currently known about the biochemical mechanism by which induced prion protein (PrP)
conformational change occurs during mammalian prion propagation. In this study, we …

Understanding the longitudinal dynamics of antibody immunity following heterologous SAR-CoV-2
breakthrough infection will inform the development of next-generation vaccines. Here…

High bone mass diseases are caused both by activating mutations in the Wnt pathway and
by loss of SOST, a bone morphogenetic protein (BMP) antagonist, leading to the activation of …

Emerging rodent-borne hantaviruses cause severe diseases in humans with no approved
vaccines or therapeutics. We recently isolated a monoclonal broadly neutralizing antibody (…

Noggin and sclerostin are bone morphogenetic protein (BMP) antagonists that modulate
mitogenic activity through sequestering BMPs. Little is known of the interactions among this …