Many bacterial systems rely on dynamic genetic circuits to control crucial biological processes.
A major goal of systems biology is to understand these behaviours in terms of individual …

… Author links open overlay panel Bruno MC Martins , James CW Locke … The work in the
Locke laboratory is also supported by a fellowship from the Gatsby Foundation (GAT3273/GLC). …

Plants are responsive to temperature, and some species can distinguish differences of 1C.
In Arabidopsis, warmer temperature accelerates flowering and increases elongation growth (…

Our computational model of the circadian clock comprised the feedback loop between LATE
ELONGATED HYPOCOTYL (LHY), CIRCADIAN CLOCK ASSOCIATED 1 (CCA1) and …

Circadian clocks involve feedback loops that generate rhythmic expression of key genes.
Molecular genetic studies in the higher plant Arabidopsis thaliana have revealed a complex …

Quantitative single-cell time-lapse microscopy is a powerful method for analyzing gene circuit
dynamics and heterogeneous cell behavior. We describe the application of this method to …

When future conditions are unpredictable, bet-hedging strategies can be advantageous.
This can involve isogenic individuals producing different phenotypes, under the same …

Circadian clocks maintain robust and accurate timing over a broad range of physiological
temperatures, a characteristic termed temperature compensation. In Arabidopsis thaliana, …

Temperature compensation contributes to the accuracy of biological timing by preventing
circadian rhythms from running more quickly at high than at low temperatures. We previously …

Circadian clocks in all organisms include feedback loops that generate rhythmic expression
of key genes. We model the first such loop proposed for the clock of Arabidopsis thaliana, …