Purpose of Review Operating rooms are critical financial centers for hospital systems, with
surgical care representing about a third of all health care spending. However, not all of the …

The origin of mutations is central to understanding evolution and of key relevance to health.
Variation occurs non-randomly across the genome, and mechanisms for this remain to be …

Centrioles are essential for ciliogenesis. However, mutations in centriole biogenesis genes
have been reported in primary microcephaly and Seckel syndrome, disorders without the …

Associations between genetic loci and increased susceptibility to autoimmune disease have
been well characterized, however, translating this knowledge into mechanistic insight and …

… Author links open overlay panel James M. Ding MD (is Candidate, Perelman School of
Medicine at the University of Pennsylvania, Philadelphia.) , Jesse M. Ehrenfeld MD, MPH (is …

Ribonucleotides are the most common noncanonical nucleotides incorporated into the
genome of replicating cells. They are efficiently removed by ribonucleotide excision repair …

Background Identification of germline mutations in DNA repair genes has significant implications
for the personalized treatment of individuals with prostate cancer (PrCa). Objective To …

Objective 1. Review our institution's experience with thyroglossal duct cyst (TGDC) excision.
2. Determine if TGDC recurrence rate is influenced by surgical technique, preoperative …

Over the past decade, genome‐wide association studies have contributed a wealth of knowledge
to our understanding of polygenic disorders such as rheumatoid arthritis. As the size of …

CD4+ T-cells represent a heterogeneous collection of specialised sub-types and are a key
cell type in the pathogenesis of many diseases due to their role in the adaptive immune …