Prostate cancer is a highly heritable disease with large disparities in incidence rates across
ancestry populations. We conducted a multiancestry meta-analysis of prostate cancer …

The transferability and clinical value of genetic risk scores (GRSs) across populations remain
limited due to an imbalance in genetic studies across ancestrally diverse populations. Here …

Background Genetic factors play an important role in prostate cancer (PCa) susceptibility.
Objective To discover common genetic variants contributing to the risk of PCa in men of African …

The prevalence of fusions of the transmembrane protease, serine 2, gene (TMPRSS2) with
the erythroblast transformation-specific–related gene (ERG), or TMPRSS2:ERG, in prostate …

Background Genome-wide association studies do not always replicate well across populations,
limiting the generalizability of polygenic risk scores (PRS). Despite higher incidence and …

Background: We recently developed a multi-ancestry polygenic risk score (PRS) that
effectively stratifies prostate cancer risk across populations. In this study, we validated the …

Genome-wide polygenic risk scores (GW-PRSs) have been reported to have better predictive
ability than PRSs based on genome-wide significance thresholds across numerous traits. …

The association between fatty acids and prostate cancer remains poorly explored in African-descent
populations. Here, we analyze 24 circulating fatty acids in 2934 men, including …

Populations in sub-Saharan Africa have historically been exposed to intense selection from
chronic infection with falciparum malaria. Interestingly, populations with the highest malaria …

There is evidence that tumor immunobiology and immunotherapy response may differ between
African American and European American prostate cancer patients. Here, we determine …