Some of the most serious consequences of ageing are its effects on skeletal muscle. The term
‘sarcopenia’ describes the slow but progressive loss of muscle mass with advancing age …

Stem cells undergo a shift in metabolic substrate utilization during specification and/or
differentiation, a process that has been termed metabolic reprogramming. Here, we report that …

The importance of β-adrenergic signaling in the heart has been well documented, but it is only
more recently that we have begun to understand the importance of this signaling pathway …

The mammalian heart undergoes maturation during postnatal life to meet the increased
functional requirements of an adult. However, the key drivers of this process remain poorly …

For many years, stem cell metabolism was viewed as a byproduct of cell fate status rather
than an active regulatory mechanism; however, there is now a growing appreciation that …

Satellite cells (SCs) sustain muscle growth and empower adult skeletal muscle with vigorous
regenerative abilities. Here, we report that EZH2, the enzymatic subunit of the Polycomb-…

β 1–3 -Adrenoreceptor (AR)-deficient mice are unable to regulate energy expenditure and
develop diet-induced obesity on a high-fat diet. We determined previously that β 2 -AR …

Muscle wasting and weakness are common in many disease states and conditions
including aging, cancer cachexia, sepsis, denervation, disuse, inactivity, burns, HIV-acquired …

A modified Chromium 10x droplet-based protocol that subsamples cells for both short-read
and long-read (nanopore) sequencing together with a new computational pipeline (FLAMES) …

The activation of AMP‐activated protein kinase (AMPK) and phosphorylation/inhibition of
acetyl‐CoA carboxylase 2 (ACC2) is believed to be the principal pathway regulating fatty acid …