We have used restriction isotyping (restriction enzyme isoform genotyping) for rapid typing
of common apolipoprotein E isoforms (E2, E3, E4). ApoE restriction isotyping used …

Age is the dominant risk factor for most chronic human diseases, but the mechanisms
through which ageing confers this risk are largely unknown 1 . The age-related acquisition of …

We conducted a meta-analysis of genome-wide association studies of systolic (SBP) and
diastolic (DBP) blood pressure in 19,608 subjects of east Asian ancestry from the AGEN-BP …

Obesity is a major predisposing factor for the development of several chronic diseases
including non-insulin dependent diabetes mellitus (NIDDM) and coronary heart disease (CHD). …

Background The familial aggregation of coronary heart disease can be in large part accounted
for by a clustering of cardiovascular disease risk factors. To elucidate the determinants of …

We carried out a trans-ancestry genome-wide association and replication study of blood
pressure phenotypes among up to 320,251 individuals of East Asian, European and South …

Chronic kidney disease (CKD), impairment of kidney function, is a serious public health
problem, and the assessment of genetic factors influencing kidney function has substantial …

Background Since insulin resistance is thought to be the underlying mechanism for metabolic
syndrome, affected individuals might be sensitive to a dietary sodium intervention. We …

In recent years, human genetic research has made dramatic advances in the identification of
molecular defects that cause rare inherited disorders. However, today's major challenge is …

Accurately determining the distribution of rare variants is an important goal of human genetics,
but resequencing of a sample large enough for this purpose has been unfeasible until …