Molecular medicine has led to rapid advances in the characterization of hepatobiliary
transport systems that determine the uptake and excretion of bile salts and other biliary …

The formation of bile is a vital function, and its impairment by drugs or infectious, autoimmune,
metabolic, or genetic disorders results in the syndrome commonly known as cholestasis. …

Bridging the gap between basic scientific advances and the understanding of liver disease—the
extensively revised new edition of the premier text in the field. The latest edition of The …

… P1B15: a cDNA clone of the rat mRNA Sessa WC, Boyer JL. Endotoxin impairs biliary …
Address requests for reprints to: James L. Boyer, MD, Department membrane proteins are …

The physiological process of bile secretion has been studied extensively and is the subject
of many reviews (1-7). During the past few years, several new aspects have been explored, …

To determine the life expectancy of patients with primary biliary cirrhosis, we analyzed
survival data from 280 patients with either symptomatic (243) or asymptomatic (37) disease. …

Recent progress in understanding the molecular mechanisms of bile formation and cholestasis
have led to new insights into the pathogenesis of drug‐induced cholestasis. This review …

The cellular and subcellular localization and mechanism of transport of the heteromeric organic
solute transporter (OST) OSTα‐OSTβ was examined in human and rodent epithelia. The …

Organic solute transporter (OSTα-OSTβ) is a novel heteromeric bile acid and sterol transporter
expressed at the basolateral membranes of epithelium in the ileum, kidney, and liver. To …

Cholestasis, including primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC),
results from an impairment or disruption of bile production and causes intracellular …