F 1 F o ATP synthase functions as a biological rotary generator that makes a major contribution
to cellular energy production. It comprises two molecular motors coupled together by a …

F 1 F o ATP synthase functions as a biological generator and makes a major contribution to
cellular energy production. Proton flow generates rotation in the F o motor that is transferred …

Cyclic peptide library screening technologies show immense promise for identifying drug
leads and chemical probes for challenging targets. However, the structural and functional …

RNA has been found to interact with chromatin and modulate gene transcription. In human
cells, little is known about how long noncoding RNAs (lncRNAs) interact with target loci in the …

Commensal bacteria serve as an important line of defense against colonisation by opportunisitic
pathogens, but the underlying molecular mechanisms remain poorly explored. Here, …

The Integrator complex can terminate RNA polymerase II (Pol II) in the promoter-proximal
region of genes. Previous work has shed light on how Integrator binds to the paused …

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Introduction: DOF proteins are a family of plant-specific transcription factors with a conserved zinc …

Almost all eukaryotic proteins receive diverse post-translational modifications (PTMs) that
modulate protein activity. Many histone PTMs are well characterized, heavily influence gene …

Chemical modifications of histone tails influence genome accessibility and the transcriptional
state of eukaryotic cells. Lysine acetylation is one of the most common modifications and …

Regulated transcription termination provides an efficient and responsive means to control
gene expression. In bacteria, rho-independent termination occurs through the formation of an …