Why prokaryotes have pangenomes

JO McInerney, A McNally, MJ O'connell - Nature microbiology, 2017 - nature.com
The existence of large amounts of within-species genome content variability is puzzling.
Population genetics tells us that fitness effects of new variants—either deleterious, neutral or …

Endosymbiotic origin and differential loss of eukaryotic genes

…, PJ Lockhart, D Bryant, E Hazkani-Covo, JO McInerney… - Nature, 2015 - nature.com
Chloroplasts arose from cyanobacteria, mitochondria arose from proteobacteria. Both
organelles have conserved their prokaryotic biochemistry, but their genomes are reduced, and …

Origins of major archaeal clades correspond to gene acquisitions from bacteria

…, G Landan, P Schönheit, B Siebers, JO McInerney… - Nature, 2015 - nature.com
The mechanisms that underlie the origin of major prokaryotic groups are poorly understood.
In principle, the origin of both species and higher taxa among prokaryotes should entail …

Networks: expanding evolutionary thinking

…, A Janke, S Kelchner, S Kelk, JO McInerney… - Trends in Genetics, 2013 - cell.com
Networks allow the investigation of evolutionary relationships that do not fit a tree model.
They are becoming a leading tool for describing the evolutionary relationships between …

The hybrid nature of the Eukaryota and a consilient view of life on Earth

JO McInerney, MJ O'connell, D Pisani - Nature Reviews Microbiology, 2014 - nature.com
The origin of the eukaryotic cell, which is known as eukaryogenesis, has puzzled scientists
for more than 100 years, and many hypotheses have been proposed. Recent analyses of …

Heterogeneous models place the root of the placental mammal phylogeny

…, D Pisani, JO McInerney, MJ O'Connell - Molecular biology …, 2013 - academic.oup.com
Heterogeneity among life traits in mammals has resulted in considerable phylogenetic conflict,
particularly concerning the position of the placental root. Layered upon this are gene- and …

Of clades and clans: terms for phylogenetic relationships in unrooted trees

M Wilkinson, JO McInerney, RP Hirt, PG Foster… - Trends in ecology & …, 2007 - cell.com
During the late 1980s, the molecular biology community became aware that the words ‘homology’and
‘similarity’were being used in much of the scientific literature as though they were …

Does a tree–like phylogeny only exist at the tips in the prokaryotes?

…, M Wilkinson, JO McInerney - … of the Royal …, 2004 - royalsocietypublishing.org
The extent to which prokaryotic evolution has been influenced by horizontal gene transfer (HGT)
and therefore might be more of a network than a tree is unclear. Here we use supertree …

[HTML][HTML] Population genomics reveal recent speciation and rapid evolutionary adaptation in polar bears

…, CC Morgan, A Doherty, MJ O'Connell, JO McInerney… - Cell, 2014 - cell.com
Polar bears are uniquely adapted to life in the High Arctic and have undergone drastic
physiological changes in response to Arctic climates and a hyperlipid diet of primarily marine …

GCUA: general codon usage analysis.

JO McInerney - Bioinformatics (Oxford, England), 1998 - academic.oup.com
The program General Codon Usage Analysis (GCUA) has been developed for analysing
codon and amino acid usage patterns. AVAILABILITY: ftp://ftp.nhm.ac.uk/pub/gcua. Freely …