User profiles for James P. Roach

James Roach

Postdoctoral Scholar; University of California Los Angeles
Verified email at ucla.edu
Cited by 318

[HTML][HTML] Choice selective inhibition drives stability and competition in decision circuits

JP Roach, AK Churchland, TA Engel - Nature communications, 2023 - nature.com
During perceptual decision-making, the firing rates of cortical neurons reflect upcoming
choices. Recent work showed that excitatory and inhibitory neurons are equally selective for …

[HTML][HTML] Connexin 43 gap junctions contribute to brain endothelial barrier hyperpermeability in familial cerebral cavernous malformations type III by modulating tight …

AM Johnson, JP Roach, A Hu, SM Stamatovic… - The FASEB …, 2018 - ncbi.nlm.nih.gov
Familial cerebral cavernous malformations type III (fCCM3) is a disease of the cerebrovascular
system caused by loss-of-function mutations in ccm3 that result in dilated capillary beds …

Resonance with subthreshold oscillatory drive organizes activity and optimizes learning in neural networks

JP Roach, A Pidde, E Katz, J Wu… - Proceedings of the …, 2018 - National Acad Sciences
Network oscillations across and within brain areas are critical for learning and performance
of memory tasks. While a large amount of work has focused on the generation of neural …

[HTML][HTML] Acetylcholine mediates dynamic switching between information coding schemes in neuronal networks

JP Roach, B Eniwaye, V Booth, LM Sander… - Frontiers in systems …, 2019 - frontiersin.org
Rate coding and phase coding are the two major coding modes seen in the brain. For these
two modes, network dynamics must either have a wide distribution of frequencies for rate …

Memory recall and spike-frequency adaptation

JP Roach, LM Sander, MR Zochowski - Physical Review E, 2016 - APS
The brain can reproduce memories from partial data; this ability is critical for memory recall.
The process of memory recall has been studied using autoassociative networks such as the …

[HTML][HTML] Formation and dynamics of waves in a cortical model of cholinergic modulation

JP Roach, E Ben-Jacob, LM Sander… - PLoS computational …, 2015 - journals.plos.org
Acetylcholine (ACh) is a regulator of neural excitability and one of the neurochemical substrates
of sleep. Amongst the cellular effects induced by cholinergic modulation are a reduction …

[HTML][HTML] 25th annual computational neuroscience meeting: CNS-2016

…, C Metzner, A Schweikard, B Zurowski, JP Roach… - BMC neuroscience, 2016 - Springer
Neural circuits are notorious for the complexity of their organization. Part of this complexity
is related to the number of different cell types that work together to encode stimuli. I will …

Social regulation of electric signal plasticity in male Brachyhypopomus gauderio

S Gavassa, JP Roach, PK Stoddard - Journal of Comparative Physiology …, 2013 - Springer
In animal communication, the social context that elicits particular dynamic changes in the
signal can provide indirect clues to signal function. Female presence should increase the …

A possible mechanism for redox control of human neuroglobin activity

AN Morozov, JP Roach, M Kotzer… - Journal of Chemical …, 2014 - ACS Publications
Neuroglobin (Ngb) promotes neuron survival under hypoxic/ischemic conditions. In vivo and
in vitro assays provide evidence for redox-regulated functioning of Ngb. On the basis of X-…

Two roles for choice selective inhibition in decision-making circuits

JP Roach, AK Churchland, TA Engel - bioRxiv, 2022 - biorxiv.org
During perceptual decision-making, the firing rates of cortical neurons reflect upcoming
choices. Recent work showed that excitatory and inhibitory neurons are equally selective for …