We have screened a subtracted cDNA library in order to identify differentially expressed
genes in omental adipose tissue of human patients with Type 2 diabetes. One clone (#1738) …

Interaction of the estrogen receptor/ligand complex with a DNA estrogen response element
is known to regulate gene transcription. In turn, specific conformations of the receptor-ligand …

When the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic emerged
in 2019, researchers rapidly recalibrated epidemiological computer models originally …

… For Mathematical Oncology to achieve its highest impact, Sluka et al argue that standards
are needed for both data and mathematical models, to ensure interoperability, to leverage and …

Toxicokinetic (TK) models link administered doses to plasma, blood, and tissue concentrations.
High-throughput TK (HTTK) performs in vitro to in vivo extrapolation to predict TK from …

The 2-arylbenzothiophene raloxifene, 1, is a selective estrogen receptor modulator (SERM)
which is currently under clinical evaluation for the prevention and treatment of …

The convergence of HPC and data intensive methodologies provide a promising approach
to major performance improvements. This paper provides a general description of the …

We describe a multi-scale, liver-centric in silico modeling framework for acetaminophen
pharmacology and metabolism. We focus on a computational model to characterize whole body …

A wide range of length and time scales are relevant to pharmacology, especially in drug
development, drug design and drug delivery. Therefore, multiscale computational modeling and …

A synthetic 52-residue peptide based on the sequence-specific DNA-binding domain of Hin
recombinase (139-190) has been equipped with ethylenediaminetetraacetic acid (EDTA) at …