Evolutionary constraint and innovation across hundreds of placental mammals
…, C Steiner, MA Supple, AP Wilder, ME Wirthlin, JR Xue… - Science, 2023 - science.org
Zoonomia is the largest comparative genomics resource for mammals produced to date. By
aligning genomes for 240 species, we identify bases that, when mutated, are likely to affect …
aligning genomes for 240 species, we identify bases that, when mutated, are likely to affect …
Mammalian evolution of human cis-regulatory elements and transcription factor binding sites
…, J Wang, Z Weng, AP Wilder, ME Wirthlin, JR Xue… - Science, 2023 - science.org
Understanding the regulatory landscape of the human genome is a long-standing objective
of modern biology. Using the reference-free alignment across 241 mammalian genomes …
of modern biology. Using the reference-free alignment across 241 mammalian genomes …
The functional and evolutionary impacts of human-specific deletions in conserved elements
Conserved genomic sequences disrupted in humans may underlie uniquely human
phenotypic traits. We identified and characterized 10,032 human-specific conserved deletions (…
phenotypic traits. We identified and characterized 10,032 human-specific conserved deletions (…
[PDF][PDF] Genome-wide functional screen of 3′ UTR variants uncovers causal variants for human disease and evolution
3′ untranslated region (3′UTR) variants are strongly associated with human traits and
diseases, yet few have been causally identified. We developed the massively parallel reporter …
diseases, yet few have been causally identified. We developed the massively parallel reporter …
Detection of Neanderthal adaptively introgressed genetic variants that modulate reporter gene expression in human immune cells
Although some variation introgressed from Neanderthals has undergone selective sweeps,
little is known about its functional significance. We used a Massively Parallel Reporter Assay …
little is known about its functional significance. We used a Massively Parallel Reporter Assay …
Vocal learning–associated convergent evolution in mammalian proteins and regulatory elements
Vocal production learning (“vocal learning”) is a convergently evolved trait in vertebrates. To
identify brain genomic elements associated with mammalian vocal learning, we integrated …
identify brain genomic elements associated with mammalian vocal learning, we integrated …
Ion association and salvation studies of liclo4/ethylene carbonate electrolyte by raman and infrared spectroscopy
Z Wang, B Huang, R Xue, L Chen… - Journal of The …, 1998 - iopscience.iop.org
Raman and infrared (IR) spectra of solutions of LiClO4 in ethylene carbonate (EC) have
been measured. Spectral changes of the ring-bending mode of EC with different LiC1O4 …
been measured. Spectral changes of the ring-bending mode of EC with different LiC1O4 …
Shift in the spatial and temporal distribution of Aedes taeniorhynchus following environmental and local developments in St. Johns County, Florida
…, MR Steck, JR Weaver, Y Zhang, R Xue… - Wetlands Ecology and …, 2022 - Springer
The Anastasia Mosquito Control District (AMCD) of St. Johns County (SJC), St. Augustine,
Florida, USA, was formed in 1948 to cover the 27 km 2 of Anastasia Island and control the …
Florida, USA, was formed in 1948 to cover the 27 km 2 of Anastasia Island and control the …
[HTML][HTML] A narrow host-range and lack of persistence in two non-target insect species of a bacterial symbiont exploited to deliver insecticidal RNAi in Western Flower …
Introduction Insecticidal RNAi is a targeted pest insect population control measure. The
specificity of insecticidal RNAi can theoretically be enhanced by using symbiotic bacteria with a …
specificity of insecticidal RNAi can theoretically be enhanced by using symbiotic bacteria with a …
Infrared spectroscopic study of the interaction between lithium salt LiClO4 and the plasticizer ethylene carbonate in the polyacrylonitrile-based electrolyte
Z Wang, B Huang, H Huang, L Chen, R Xue, F Wang - Solid state ionics, 1996 - Elsevier
The infrared (IR) spectra of ethylene carbonate (EC) containing different contents of lithium
perchlorate (LiClO 4 ) have been measured and analyzed. It is found that, with the increase of …
perchlorate (LiClO 4 ) have been measured and analyzed. It is found that, with the increase of …