Two classes of sequences in the yeast Saccharomyces cerevisiae are subject to transcriptional
silencing: the silent mating-type cassettes and telomeres. In this report we demonstrate …

The Target of Rapamycin (TOR) protein is a Ser/Thr kinase that functions in two distinct
multiprotein complexes: TORC1 and TORC2. These conserved complexes regulate many …

Cell-size homeostasis entails a fundamental balance between growth and division. The
budding yeast Saccharomyces cerevisiae establishes this balance by enforcing growth to a …

We have constructed a plasmid, YEp13, which when used in conjunction with transformation
in yeast is a suitable vector for isolating specific yeast genes. The plasmid consists of …

Availability of key nutrients, such as sugars, amino acids, and nitrogen compounds, dictates
the developmental programs and the growth rates of yeast cells. A number of overlapping …

Yeast cells sense the amount and quality of external nutrients through multiple interconnected
signaling networks, which allow them to adjust their metabolism, transcriptional profile …

Recent progress in elucidating the mechanisms underlying human disease has dramatically
increased the number of protein targets available for potential drug treatment. Concurrently, …

Heterochromatin in metazoans induces transcriptional silencing, as exemplified by position
effect variegation in Drosophila melanogaster and X-chromosome inactivation in mammals. …

Tor proteins, homologous to DNA-dependent protein kinases, participate in a signal transduction
pathway in yeast that regulates protein synthesis and cell wall expansion in response …

Structural variants (SVs) can contribute to oncogenesis through a variety of mechanisms.
Despite their importance, the identification of SVs in cancer genomes remains challenging. …