User profiles for James R. Roede

James R. Roede

University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences
Verified email at ucdenver.edu
Cited by 1896

[PDF][PDF] Non-enzymatic lysine lactoylation of glycolytic enzymes

…, M Johannsen, DA Spiegel, E Chapman, JR Roede… - Cell chemical …, 2020 - cell.com
Post-translational modifications (PTMs) regulate enzyme structure and function to expand
the functional proteome. Many of these PTMs are derived from cellular metabolites and serve …

[HTML][HTML] Serum metabolomics of slow vs. rapid motor progression Parkinson's disease: a pilot study

JR Roede, K Uppal, Y Park, K Lee, V Tran, D Walker… - PloS one, 2013 - journals.plos.org
Progression of Parkinson’s disease (PD) is highly variable, indicating that differences between
slow and rapid progression forms could provide valuable information for improved early …

4-Hydroxynonenal inhibits SIRT3 via thiol-specific modification

…, JJ Galligan, RL Smathers, JR Roede… - Chemical research in …, 2011 - ACS Publications
4-Hydroxynonenal (4-HNE) is an endogenous product of lipid peroxidation known to play a
role in cellular signaling through protein modification and is a major precursor for protein …

Reactive species and mitochondrial dysfunction: mechanistic significance of 4‐hydroxynonenal

JR Roede, DP Jones - Environmental and molecular …, 2010 - Wiley Online Library
Mitochondrial dysfunction is a global term used in the context of “unhealthy” mitochondria.
In practical terms, mitochondria are extremely complex and highly adaptive in structure, …

[HTML][HTML] Selective targeting of the cysteine proteome by thioredoxin and glutathione redox systems

YM Go, JR Roede, DI Walker, DM Duong… - Molecular & Cellular …, 2013 - ASBMB
Thioredoxin (Trx) and GSH are the major thiol antioxidants protecting cells from oxidative
stress-induced cytotoxicity. Redox states of Trx and GSH have been used as indicators of …

Integrated redox proteomics and metabolomics of mitochondria to identify mechanisms of cd toxicity

YM Go, JR Roede, M Orr, Y Liang… - Toxicological …, 2014 - academic.oup.com
Cadmium (Cd) exposure contributes to human diseases affecting liver, kidney, lung, and
other organ systems, but mechanisms underlying the pleotropic nature of these toxicities are …

Sugarcane ash and sugarcane ash-derived silica nanoparticles alter cellular metabolism in human proximal tubular kidney cells

AD Stem, KL Rogers, JR Roede… - Environmental …, 2023 - Elsevier
Multiple epidemics of chronic kidney disease of an unknown etiology (CKDu) have emerged
in agricultural communities around the world. Many factors have been posited as potential …

[HTML][HTML] The burden of trisomy 21 disrupts the proteostasis network in Down syndrome

…, H Jiang, LA Liggett, KN Maclean, JR Roede - Plos one, 2017 - journals.plos.org
Down syndrome (DS) is a genetic disorder caused by trisomy of chromosome 21. Abnormalities
in chromosome number have the potential to lead to disruption of the proteostasis …

[HTML][HTML] Chronic ethanol consumption induces mitochondrial protein acetylation and oxidative stress in the kidney

…, DJ Orlicky, Y Liang, CT Shearn, JR Roede… - Redox biology, 2015 - Elsevier
In this study, we present the novel findings that chronic ethanol consumption induces
mitochondrial protein hyperacetylation in the kidney and correlates with significantly increased …

Posttranslational modification and regulation of glutamate–cysteine ligase by the α, β-unsaturated aldehyde 4-hydroxy-2-nonenal

DS Backos, KS Fritz, JR Roede, DR Petersen… - Free Radical Biology …, 2011 - Elsevier
4-Hydroxy-2-nonenal (4-HNE) is a lipid peroxidation product formed during oxidative stress
that can alter protein function via adduction of nucleophilic amino acid residues. 4-HNE …