User profiles for James R. Roede
James R. RoedeUniversity of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences Verified email at ucdenver.edu Cited by 1896 |
[PDF][PDF] Non-enzymatic lysine lactoylation of glycolytic enzymes
Post-translational modifications (PTMs) regulate enzyme structure and function to expand
the functional proteome. Many of these PTMs are derived from cellular metabolites and serve …
the functional proteome. Many of these PTMs are derived from cellular metabolites and serve …
[HTML][HTML] Serum metabolomics of slow vs. rapid motor progression Parkinson's disease: a pilot study
Progression of Parkinson’s disease (PD) is highly variable, indicating that differences between
slow and rapid progression forms could provide valuable information for improved early …
slow and rapid progression forms could provide valuable information for improved early …
4-Hydroxynonenal inhibits SIRT3 via thiol-specific modification
…, JJ Galligan, RL Smathers, JR Roede… - Chemical research in …, 2011 - ACS Publications
4-Hydroxynonenal (4-HNE) is an endogenous product of lipid peroxidation known to play a
role in cellular signaling through protein modification and is a major precursor for protein …
role in cellular signaling through protein modification and is a major precursor for protein …
Reactive species and mitochondrial dysfunction: mechanistic significance of 4‐hydroxynonenal
Mitochondrial dysfunction is a global term used in the context of “unhealthy” mitochondria.
In practical terms, mitochondria are extremely complex and highly adaptive in structure, …
In practical terms, mitochondria are extremely complex and highly adaptive in structure, …
[HTML][HTML] Selective targeting of the cysteine proteome by thioredoxin and glutathione redox systems
Thioredoxin (Trx) and GSH are the major thiol antioxidants protecting cells from oxidative
stress-induced cytotoxicity. Redox states of Trx and GSH have been used as indicators of …
stress-induced cytotoxicity. Redox states of Trx and GSH have been used as indicators of …
Integrated redox proteomics and metabolomics of mitochondria to identify mechanisms of cd toxicity
Cadmium (Cd) exposure contributes to human diseases affecting liver, kidney, lung, and
other organ systems, but mechanisms underlying the pleotropic nature of these toxicities are …
other organ systems, but mechanisms underlying the pleotropic nature of these toxicities are …
Sugarcane ash and sugarcane ash-derived silica nanoparticles alter cellular metabolism in human proximal tubular kidney cells
AD Stem, KL Rogers, JR Roede… - Environmental …, 2023 - Elsevier
Multiple epidemics of chronic kidney disease of an unknown etiology (CKDu) have emerged
in agricultural communities around the world. Many factors have been posited as potential …
in agricultural communities around the world. Many factors have been posited as potential …
[HTML][HTML] The burden of trisomy 21 disrupts the proteostasis network in Down syndrome
…, H Jiang, LA Liggett, KN Maclean, JR Roede - Plos one, 2017 - journals.plos.org
Down syndrome (DS) is a genetic disorder caused by trisomy of chromosome 21. Abnormalities
in chromosome number have the potential to lead to disruption of the proteostasis …
in chromosome number have the potential to lead to disruption of the proteostasis …
[HTML][HTML] Chronic ethanol consumption induces mitochondrial protein acetylation and oxidative stress in the kidney
In this study, we present the novel findings that chronic ethanol consumption induces
mitochondrial protein hyperacetylation in the kidney and correlates with significantly increased …
mitochondrial protein hyperacetylation in the kidney and correlates with significantly increased …
Posttranslational modification and regulation of glutamate–cysteine ligase by the α, β-unsaturated aldehyde 4-hydroxy-2-nonenal
4-Hydroxy-2-nonenal (4-HNE) is a lipid peroxidation product formed during oxidative stress
that can alter protein function via adduction of nucleophilic amino acid residues. 4-HNE …
that can alter protein function via adduction of nucleophilic amino acid residues. 4-HNE …