User profiles for James TR Walters
James WaltersCardiff University Verified email at cf.ac.uk Cited by 43718 |
Treatment-resistant schizophrenia: treatment response and resistance in psychosis (TRRIP) working group consensus guidelines on diagnosis and terminology
…, A Üçok, D Umbricht, JTR Walters… - American Journal of …, 2017 - Am Psychiatric Assoc
Objective: Research and clinical translation in schizophrenia is limited by inconsistent
definitions of treatment resistance and response. To address this issue, the authors evaluated …
definitions of treatment resistance and response. To address this issue, the authors evaluated …
Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection
Schizophrenia is a debilitating psychiatric condition often associated with poor quality of life
and decreased life expectancy. Lack of progress in improving treatment outcomes has been …
and decreased life expectancy. Lack of progress in improving treatment outcomes has been …
[PDF][PDF] Modeling linkage disequilibrium increases accuracy of polygenic risk scores
Polygenic risk scores have shown great promise in predicting complex disease risk and will
become more accurate as training sample sizes increase. The standard approach for …
become more accurate as training sample sizes increase. The standard approach for …
[HTML][HTML] Genomic findings in schizophrenia and their implications
There has been substantial progress in understanding the genetics of schizophrenia over
the past 15 years. This has revealed a highly polygenic condition with the majority of the …
the past 15 years. This has revealed a highly polygenic condition with the majority of the …
Heritability of neuropsychological measures in schizophrenia and nonpsychiatric populations: a systematic review and meta-analysis
…, LE DeLisi, G Donohoe, JTR Walters… - Schizophrenia …, 2017 - academic.oup.com
Schizophrenia is characterized by neuropsychological deficits across many cognitive
domains. Cognitive phenotypes with high heritability and genetic overlap with schizophrenia …
domains. Cognitive phenotypes with high heritability and genetic overlap with schizophrenia …
[PDF][PDF] Partitioning heritability of regulatory and cell-type-specific variants across 11 common diseases
Regulatory and coding variants are known to be enriched with associations identified by
genome-wide association studies (GWASs) of complex disease, but their contributions to trait …
genome-wide association studies (GWASs) of complex disease, but their contributions to trait …
Integrative functional genomic analysis of human brain development and neuropsychiatric risks
INTRODUCTION The brain is responsible for cognition, behavior, and much of what makes
us uniquely human. The development of the brain is a highly complex process, and this …
us uniquely human. The development of the brain is a highly complex process, and this …
Genetic identification of brain cell types underlying schizophrenia
With few exceptions, the marked advances in knowledge about the genetic basis of schizophrenia
have not converged on findings that can be confidently used for precise experimental …
have not converged on findings that can be confidently used for precise experimental …
Mapping genomic loci prioritises genes and implicates synaptic biology in schizophrenia
…, S Ripke, JTR Walters… - MedRxiv, 2020 - medrxiv.org
Schizophrenia is a psychiatric disorder whose pathophysiology is largely unknown. It has a
heritability of 60-80%, much of which is attributable to common risk alleles, suggesting …
heritability of 60-80%, much of which is attributable to common risk alleles, suggesting …
Analysis of copy number variations at 15 schizophrenia-associated loci
E Rees, JTR Walters, L Georgieva, AR Isles… - The British Journal of …, 2014 - cambridge.org
BackgroundA number of copy number variants (CNVs) have been suggested as susceptibility
factors for schizophrenia. For some of these the data remain equivocal, and the frequency …
factors for schizophrenia. For some of these the data remain equivocal, and the frequency …