Background Somatic mutations in the kinase domain of the epidermal growth factor receptor
tyrosine kinase gene EGFR are common in lung adenocarcinoma. The presence of …

Somatic mutations in the epidermal growth factor receptor (EGFR) occur frequently in lung
cancer and confer sensitivity to EGFR kinase inhibitors gefitinib and erlotinib. These mutations…

Signal transducer and activator of transcription 3 (STAT3) is a transcription factor that is
activated in diverse human tumors and may play a direct role in malignant transformation. …

The survival and recurrence of dormant tumour cells following therapy is a leading cause of
death in patients with cancer. The metabolic properties of these cells are likely to be distinct …

10.7554/eLife.43653.001 Over half of breast-cancer-related deaths are due to recurrence 5
or more years after initial diagnosis and treatment. This latency suggests that a population of …

Most deaths from breast cancer result from tumor recurrence, but mechanisms underlying
tumor relapse are largely unknown. We now report that Par-4 is downregulated during tumor …

Inappropriate activation of transcription factors is a common event in cancer. These transcription
factors contribute to a malignant phenotype by regulating genes involved in cellular …

Extrapituitary prolactin (Prl) is produced in humans and rodents; however, little is known
about its in vivo regulation or physiological function. We now report that autocrine prolactin is …

Recurrent breast cancer presents significant challenges with aggressive phenotypes and
treatment resistance. Therefore, novel therapeutics are urgently needed. Here, we report that …

Increased glucose utilization is a hallmark of human cancer that is used to image tumors
clinically. In this widely used application, glucose uptake by tumors is monitored by positron …