A fundamental goal of cell biology is to define the functions of proteins in the context of
compartments that organize them in the cellular environment. Here we describe the construction …

The cytokine TNF is a critical mediator of immune and inflammatory responses. The TNF
gene is an immediate early gene, rapidly transcribed in a variety of cell types following …

In this paper, we investigate DNA bending induced by proteins required for virus induction
of the human interferon-p (IFNp) gene. We showthat NF-KB-DNA~~~-plexes that are …

The tumor necrosis factor alpha (TNF-α) gene is rapidly activated by lipopolysaccharide (LPS).
Here, we show that extracellular signal-regulated kinase (ERK) kinase activity but not …

Heterodimeric transcription factors, including the basic region-leucine zipper (bZIP) protein
ATF-2–c-jun, are well-characterized components of an enhanceosome that mediates virus …

The human tumor necrosis factor alpha (TNF-α) gene is rapidly activated in response to
multiple signals of stress and inflammation. We have identified transcription factors present in …

A major challenge in the post‐genomic era is the development of experimental approaches
to monitor the properties of proteins on a proteome‐wide level. It would be particularly useful …

The interferon (IFN)-induced transmembrane (IFITM) proteins are critical mediators of the
host antiviral response. Here, we expand the role of IFITM proteins to host defense against …

Epigenetics encompasses transient and heritable modifications to DNA and nucleosomes in
the native chromatin context. For example, enzymatic addition of chemical moieties to the N-…

Here we provide a mechanism for specific, efficient transcription of the TNF gene and,
potentially, other genes residing within multigene loci. We identify and characterize highly …