Autophagy is a powerful tool that host cells use to defend against viral infection. Double-membrane
vesicles, termed autophagosomes, deliver trapped viral cargo to the lysosome for …

Linear ubiquitination is a newly discovered posttranslational modification that is currently
restricted to a small number of known protein substrates. The linear ubiquitination assembly …

Blood CD14 + monocytes are frontline immunomodulators categorized into classical,
intermediate or non-classical subsets, and subsequently differentiated into M1 pro- or M2 anti-…

RIPK3–ZBP1–MLKL-mediated necroptosis is a proinflammatory cell death process that is
crucial for antiviral host defence. RIPK3 self-oligomerization and autophosphorylation are …

Many bacteria, including Legionella pneumophila, rely on the type IV secretion system to
translocate a repertoire of effector proteins into the hosts for their survival and growth. Type IV …

Significance: The autophagy and inflammasome pathways are ancient innate immune
mechanisms for controlling invading pathogens that are linked by mutual regulation. In addition to …

Despite SARS-CoV-2 being a "novel" virus, early detection of anti-spike IgG in severe
COVID-19 patients may be caused by the amplification of humoral memory responses against …

Thioredoxin-interacting protein (TXNIP) has emerged as a key player in cancer and diabetes
since it targets thioredoxin (TRX)-mediated redox regulation and glucose transporter (GLUT…

… Youn Jung Choi,1,2 James W. Bowman,1,2 and Jae U. Jung1,* 1Department of Molecular
Microbiology and Immunology, Keck School of Medicine, University of Southern California …

Host-pathogen interactions drive an evolutionary game of cat-and-mouse between a pathogen’s
protein virulence factors, the host’s adaptive immune system, and therapeutics targeting …