FOXF1 transcription factor is required for formation of embryonic vasculature by regulating VEGF signaling in endothelial cells

…, V Ustiyan, A Pradhan, Y Cai, JA Havrilak… - Circulation …, 2014 - Am Heart Assoc
Rationale: Inactivating mutations in the Forkhead Box transcription factor F1 (FOXF1) gene
locus are frequently found in patients with alveolar capillary dysplasia with misalignment of …

[HTML][HTML] Characterization of the dynamics and variability of neuronal subtype responses during growth, degrowth, and regeneration of Nematostella vectensis

JA Havrilak, L Al-Shaer, N Baban, N Akinci, MJ Layden - BMC biology, 2021 - Springer
Background The ability to regenerate body parts is a feature of metazoan organisms and the
focus of intense research aiming to understand its basis. A number of mechanisms involved …

[HTML][HTML] Characterization of NvLWamide-like neurons reveals stereotypy in Nematostella nerve net development

JA Havrilak, D Faltine-Gonzalez, Y Wen, D Fodera… - Developmental …, 2017 - Elsevier
The organization of cnidarian nerve nets is traditionally described as diffuse with randomly
arranged neurites that show minimal reproducibility between animals. However, most …

[HTML][HTML] Endothelial cells are not required for specification of respiratory progenitors

JA Havrilak, KR Melton, JM Shannon - Developmental biology, 2017 - Elsevier
Crosstalk between mesenchymal and epithelial cells influences organogenesis in multiple
tissues, such as lung, pancreas, liver, and the nervous system. Lung mesenchyme comprises …

Branching of lung epithelium in vitro occurs in the absence of endothelial cells

JA Havrilak, JM Shannon - Developmental Dynamics, 2015 - Wiley Online Library
Background: Early lung morphogenesis is driven by tissue interactions. Signals from the lung
mesenchyme drive epithelial morphogenesis, but which individual mesenchymal cell types …

Are you paying attention? Female wolf spiders increase dragline silk advertisements when males do not court

JA Havrilak, KM Shimmel, AL Rypstra, MH Persons - Ethology, 2015 - Wiley Online Library
Females of many spider species invest in chemical advertisements to attract males, yet
variation in investment relative to the presence or quality of males remains poorly understood. …

Dynamics and variability of neuronal subtype responses during growth, degrowth, and regeneration

JA Havrilak, L Al-Shaer, N Baban, N Akinci, MJ Layden - bioRxiv, 2019 - biorxiv.org
Background We are interested in nervous system dynamics in adult and regenerating
animals. Preliminary studies suggest that some species alter neuronal number to scale with …

[HTML][HTML] MAPK signaling is necessary for neurogenesis in Nematostella vectensis

MJ Layden, H Johnston, AR Amiel, J Havrilak… - BMC biology, 2016 - Springer
Background The nerve net of Nematostella is generated using a conserved cascade of
neurogenic transcription factors. For example, NvashA, a homolog of the achaete-scute family of …

Reverse Genetic Approaches to Investigate the Neurobiology of the Cnidarian Sea Anemone Nematostella vectensis

JA Havrilak, MJ Layden - Brain Development: Methods and Protocols, 2020 - Springer
The cnidarian sea anemone Nematostella vectensis has grown in popularity as a model
system to complement the ongoing work in traditional bilaterian model species (eg Drosophila, …

Nematostella vectensis as a Model System

L Al-Shaer, J Havrilak, MJ Layden - Handbook of Marine Model …, 2021 - taylorfrancis.com
Nematostella vectensis is an established cnidarian model system. One of the greatest
contributions to the growing momentum of this model is the ability to compare multiple …