Signal transduction pathways play diverse, context-dependent roles in vertebrate development.
In studies of human embryonic stem cells (hESCs), conflicting reports claim Wnt/β-…

Wnt/β-catenin signaling can influence the proliferation and differentiation of progenitor
populations in the hippocampus and subventricular zone, known germinal centers in the adult …

Heart disease is the leading cause of death with no method to repair damaged myocardium
due to the limited proliferative capacity of adult cardiomyocytes. Curiously, mouse neonates …

Exposure to air pollution has long been known to trigger cardiovascular events, primarily
through activation of local and systemic inflammatory pathways that affect the vasculature. …

Elevated levels of nuclear β‐catenin are associated with higher rates of survival in patients
with melanoma, raising questions as to how ß‐catenin is regulated in this context. In the …

In utero exposure to diesel exhaust air pollution has been associated with increased adult
susceptibility to heart failure in mice, but the mechanisms by which this exposure promotes …

Background Developmental exposure to particulate matter air pollution is harmful to
cardiovascular health, but the mechanisms by which this exposure mediates susceptibility to heart …

In storing and transmitting epigenetic information, organisms must balance the need to
maintain information about past conditions with the capacity to respond to information in their …

In utero exposure to diesel exhaust air pollution has been associated with increased adult
susceptibility to heart failure in mice but the mechanisms by which this exposure promotes …

DNA methylation has been studied extensively in many developmental systems. Little attention,
however, has been given to identifying methylation features that distinguish loci whose …