[HTML][HTML] Activation of caspase pathways during iron chelator-mediated apoptosis
…, RP Planalp, MW Brechbiel, J Jennings-Gee… - Journal of Biological …, 2002 - ASBMB
Iron chelators have traditionally been used in the treatment of iron overload. Recently,
chelators have also been explored for their ability to limit oxidant damage in cardiovascular, …
chelators have also been explored for their ability to limit oxidant damage in cardiovascular, …
Hyperbiofilm formation by Bordetella pertussis strains correlates with enhanced virulence traits
N Cattelan, J Jennings-Gee, P Dubey… - Infection and …, 2017 - Am Soc Microbiol
Pertussis, or whooping cough, caused by the obligate human pathogen Bordetella pertussis
is undergoing a worldwide resurgence. The majority of studies of this pathogen are …
is undergoing a worldwide resurgence. The majority of studies of this pathogen are …
In utero Exposure of Mice to Dibenzo[a,l]Pyrene Produces Lymphoma in the Offspring: Role of the Aryl Hydrocarbon Receptor
…, NI Kerkvliet, CB Pereira, JE Jennings-Gee… - Cancer research, 2006 - AACR
Lymphoma and leukemia are the most common cancers in children and young adults; in
utero carcinogen exposure may contribute to the etiology of these cancers. A polycyclic …
utero carcinogen exposure may contribute to the etiology of these cancers. A polycyclic …
[HTML][HTML] Ochratoxin A: In Utero Exposure in Mice Induces Adducts in Testicular DNA
JE Jennings-Gee, M Tozlovanu, R Manderville… - Toxins, 2010 - mdpi.com
Ochratoxin A (OTA) is a nephrotoxin and carcinogen that is associated with Balkan endemic
nephropathy and urinary tract tumors. OTA crosses the placenta and causes adducts in the …
nephropathy and urinary tract tumors. OTA crosses the placenta and causes adducts in the …
Unique dual targeting of thymidylate synthase and topoisomerase1 by FdUMP [10] results in high efficacy against AML and low toxicity
TS Pardee, E Gomes, J Jennings-Gee… - Blood, The Journal …, 2012 - ashpublications.org
Acute myeloid leukemia (AML) is an aggressive malignancy that leads to marrow failure
and death. There is a desperate need for new therapies. The novel fluoropyrimidine, FdUMP[10]…
and death. There is a desperate need for new therapies. The novel fluoropyrimidine, FdUMP[10]…
Hyperglucosuria induced by dapagliflozin augments bacterial colonization in the murine urinary tract
P Saenkham, J Jennings‐Gee… - Diabetes, Obesity …, 2020 - Wiley Online Library
… Panatda Saenkham and Jamie Jennings-Gee contributed equally to this study. This work
was supported by institutional funds, and a pilot grant from the Center for Diabetes, Obesity …
was supported by institutional funds, and a pilot grant from the Center for Diabetes, Obesity …
[HTML][HTML] Selective anti-tumor activity of the novel fluoropyrimidine polymer F10 towards G48a orthotopic GBM tumors
…, C Lema-Tome, D Gibo, J Jennings-Gee… - Journal of neuro …, 2014 - Springer
F10 is a novel anti-tumor agent with minimal systemic toxicity in vivo and which displays strong
cytotoxicity towards glioblastoma (GBM) cells in vitro. Here we investigate the cytotoxicity …
cytotoxicity towards glioblastoma (GBM) cells in vitro. Here we investigate the cytotoxicity …
Association of autoimmune thyroid disease with a microsatellite marker for the thyrotropin receptor gene and CTLA-4 in a Japanese population.
…, H Iwasaki, SS Rich, JE Jennings-Gee… - Proceedings of the …, 1997 - europepmc.org
To examine the genetic contribution of the thyroid-stimulating hormone receptor (TSHR, or
thyrotropin receptor) gene to autoimmune thyroid disease (AITD), we identified a dinucleotide …
thyrotropin receptor) gene to autoimmune thyroid disease (AITD), we identified a dinucleotide …
The adjuvant Bordetella colonization factor A attenuates alum-induced Th2 responses and enhances Bordetella pertussis clearance from mouse lungs
J Jennings-Gee, S Quataert, T Ganguly… - Infection and …, 2018 - Am Soc Microbiol
The reemergence of pertussis or whooping cough in several countries highlights the need
for better vaccines. Acellular pertussis vaccines (aPV) contain alum as the adjuvant and elicit …
for better vaccines. Acellular pertussis vaccines (aPV) contain alum as the adjuvant and elicit …
Thymineless death in F10-treated AML cells occurs via lipid raft depletion and Fas/FasL co-localization in the plasma membrane with activation of the extrinsic …
WH Gmeiner, J Jennings-Gee, CH Stuart, TS Pardee - Leukemia research, 2015 - Elsevier
The polymeric fluoropyrimidine F10 displays excellent anti-leukemia activity in pre-clinical
models of acute myelogenous leukemia (AML) through dual targeting of thymidylate synthase …
models of acute myelogenous leukemia (AML) through dual targeting of thymidylate synthase …