Stop codon readthrough (SCR) occurs when the ribosome miscodes at a stop codon. Such
readthrough events can be therapeutically desirable when a premature termination codon (…

Ribosome footprint profiling is a high-throughput sequencing–based technique that provides
detailed and global views of translation in living cells. An essential part of this technology is …

Introduction While multidimensional flow cytometry (MDF) has great utility in diagnostic workups
of patients with suspected myelodysplastic syndromes (MDS), only the myeloid lineage …

To successfully conclude protein synthesis, the ribosome must accurately terminate translation
upon reaching the termination codon at the end of a coding sequence. Failure to do so …

Introduction The extension of quantitative flow cytometric studies to the erythroid lineage in
patients with suspected myelodysplastic syndrome has prompted a reassessment of cell …

… First, Wangen and Green used ribosomal profiling to examine translation in human cells
treated with the aminoglycoside G418. Cells that were exposed to G418 had fewer ribosomes …

Protein synthesis continues in platelets and maturing reticulocytes, although these blood
cells lack nuclei and do not make new mRNA or ribosomes. Here, we analyze translation in …

Premature termination codons (PTCs) prevent translation of a full-length protein and trigger
nonsense-mediated mRNA decay (NMD). Nonsense suppression (also termed readthrough) …

The homologous genes GTPBP1 and GTPBP2 encode GTP-binding proteins 1 and 2,
which are involved in ribosomal homeostasis. Pathogenic variants in GTPBP2 were recently …

Purpose Lung cancer is the leading cause of cancer death, but the advent of lung cancer
screening using low-dose computed tomography offers a tremendous opportunity to improve …