[HTML][HTML] Microglia regulate central nervous system myelin growth and integrity
…, W Mungall, M Dodds, C Dittmayer, J Moss, J Rose… - Nature, 2023 - nature.com
Myelin is required for the function of neuronal axons in the central nervous system, but the
mechanisms that support myelin health are unclear. Although macrophages in the central …
mechanisms that support myelin health are unclear. Although macrophages in the central …
[HTML][HTML] Reactive astrocytes acquire neuroprotective as well as deleterious signatures in response to Tau and Aß pathology
…, X He, J Fowler, J Febery, J Gregory, J Rose… - Nature …, 2022 - nature.com
Alzheimer’s disease (AD) alters astrocytes, but the effect of Aß and Tau pathology is poorly
understood. TRAP-seq translatome analysis of astrocytes in APP/PS1 ß-amyloidopathy and …
understood. TRAP-seq translatome analysis of astrocytes in APP/PS1 ß-amyloidopathy and …
[PDF][PDF] Major shifts in glial regional identity are a transcriptional hallmark of human brain aging
Gene expression studies suggest that aging of the human brain is determined by a complex
interplay of molecular events, although both its region- and cell-type-specific consequences …
interplay of molecular events, although both its region- and cell-type-specific consequences …
[PDF][PDF] Synaptic oligomeric tau in Alzheimer's disease—a potential culprit in the spread of tau pathology through the brain
…, YY Chang, K Holt, RI McGeachan, J Rose… - Neuron, 2023 - cell.com
In Alzheimer's disease, fibrillar tau pathology accumulates and spreads through the brain
and synapses are lost. Evidence from mouse models indicates that tau spreads trans-…
and synapses are lost. Evidence from mouse models indicates that tau spreads trans-…
Biased agonists of the kappa opioid receptor suppress pain and itch without causing sedation or dysphoria
TF Brust, J Morgenweck, SA Kim, JH Rose, JL Locke… - Science …, 2016 - science.org
Agonists targeting the kappa opioid receptor (KOR) have been promising therapeutic
candidates because of their efficacy for treating intractable itch and relieving pain. Unlike typical …
candidates because of their efficacy for treating intractable itch and relieving pain. Unlike typical …
Dopamine transporters govern diurnal variation in extracellular dopamine tone
…, JK Konstantopoulos, JH Rose… - Proceedings of the …, 2014 - National Acad Sciences
The majority of neurotransmitter systems shows variations in state-dependent cell firing
rates that are mechanistically linked to variations in extracellular levels, or tone, of their …
rates that are mechanistically linked to variations in extracellular levels, or tone, of their …
[PDF][PDF] TDP-43 depletion in microglia promotes amyloid clearance but also induces synapse loss
…, A Valeri, M Merlini, JL Robinson, EB Lee, J Rose… - Neuron, 2017 - cell.com
Microglia coordinate various functions in the central nervous system ranging from removing
synaptic connections, to maintaining brain homeostasis by monitoring neuronal function, …
synaptic connections, to maintaining brain homeostasis by monitoring neuronal function, …
[PDF][PDF] Amyloid beta and tau cooperate to cause reversible behavioral and transcriptional deficits in a model of Alzheimer's disease
…, A Anton-Fernandez, D King, I Oren, J Rose… - Cell reports, 2019 - cell.com
A key knowledge gap blocking development of effective therapeutics for Alzheimer's disease
(AD) is the lack of understanding of how amyloid beta (Aβ) peptide and pathological forms …
(AD) is the lack of understanding of how amyloid beta (Aβ) peptide and pathological forms …
Effects of chronic ethanol exposure on neuronal function in the prefrontal cortex and extended amygdala
Chronic alcohol consumption and withdrawal leads to anxiety, escalated alcohol drinking
behavior, and alcohol dependence. Alterations in the function of key structures within the …
behavior, and alcohol dependence. Alterations in the function of key structures within the …
[HTML][HTML] PrP is a central player in toxicity mediated by soluble aggregates of neurodegeneration-causing proteins
Neurodegenerative diseases are an enormous public health problem, affecting tens of millions
of people worldwide. Nearly all of these diseases are characterized by oligomerization …
of people worldwide. Nearly all of these diseases are characterized by oligomerization …