Myelin is required for the function of neuronal axons in the central nervous system, but the
mechanisms that support myelin health are unclear. Although macrophages in the central …

Alzheimer’s disease (AD) alters astrocytes, but the effect of Aß and Tau pathology is poorly
understood. TRAP-seq translatome analysis of astrocytes in APP/PS1 ß-amyloidopathy and …

Gene expression studies suggest that aging of the human brain is determined by a complex
interplay of molecular events, although both its region- and cell-type-specific consequences …

In Alzheimer's disease, fibrillar tau pathology accumulates and spreads through the brain
and synapses are lost. Evidence from mouse models indicates that tau spreads trans-…

Agonists targeting the kappa opioid receptor (KOR) have been promising therapeutic
candidates because of their efficacy for treating intractable itch and relieving pain. Unlike typical …

The majority of neurotransmitter systems shows variations in state-dependent cell firing
rates that are mechanistically linked to variations in extracellular levels, or tone, of their …

Microglia coordinate various functions in the central nervous system ranging from removing
synaptic connections, to maintaining brain homeostasis by monitoring neuronal function, …

A key knowledge gap blocking development of effective therapeutics for Alzheimer's disease
(AD) is the lack of understanding of how amyloid beta (Aβ) peptide and pathological forms …

Chronic alcohol consumption and withdrawal leads to anxiety, escalated alcohol drinking
behavior, and alcohol dependence. Alterations in the function of key structures within the …

Neurodegenerative diseases are an enormous public health problem, affecting tens of millions
of people worldwide. Nearly all of these diseases are characterized by oligomerization …