Background Ageing is associated with DNA methylation changes in all human tissues, and
epigenetic markers can estimate chronological age based on DNA methylation patterns …

Exercise training prevents age‐related decline in muscle function. Targeting epigenetic aging
is a promising actionable mechanism and late‐life exercise mitigates epigenetic aging in …

Background Knowledge of age‐related DNA methylation changes in skeletal muscle is limited,
yet this tissue is severely affected by ageing in humans. Methods We conducted a large‐…

Skeletal muscle unloading due to joint immobilization induces muscle atrophy, which has
primarily been attributed to reductions in protein synthesis in humans. However, no study has …

Phenotypic and transcriptomic evidence of early cardiac aging, and associated mechanisms,
were investigated in young to middle-aged male mice (C57Bl/6; ages 8, 16, 32, 48 wks). …

New Findings What is the central question of this study? The extent to which genetics determines
adaptation to endurance versus resistance exercise is unclear. Previously, a divergent …

Skeletal muscle atrophy is a physiological response to disuse, aging, and disease. We
compared changes in muscle mass and the transcriptome profile after short-term immobilization …

Exercise training prevents age-related decline in muscle function. Targeting epigenetic aging
is a promising actionable mechanism and late-life exercise mitigates epigenetic aging in …

Targeted screening for dementia among older adults in primary healthcare has potential
benefits such as better clinical outcomes and the opportunity to access services. Cognitive …

Neutrophil extracellular traps (NETs) not only counteract bacterial and fungal pathogens but
can also promote thrombosis, autoimmunity, and sterile inflammation. The presence of …