User profiles for Jan B. van Klinken
 | Jan Bert van KlinkenAmsterdam University Medical Centre & Leiden University Medical Centre Verified email at lumc.nl Cited by 3804 |
Blocking FSH induces thermogenic adipose tissue and reduces body fat
…, NG Avadhani, MI New, H Molina, JB Van Klinken… - Nature, 2017 - nature.com
Menopause is associated with bone loss and enhanced visceral adiposity. A polyclonal
antibody that targets the β-subunit of the pituitary hormone follicle-stimulating hormone (Fsh) …
antibody that targets the β-subunit of the pituitary hormone follicle-stimulating hormone (Fsh) …
Brown adipose tissue volume in healthy lean south Asian adults compared with white Caucasians: a prospective, case-controlled observational study
…, LP Arias-Bouda, JB van Klinken… - The lancet Diabetes & …, 2014 - thelancet.com
Background Individuals of south Asian origin have a very high risk of developing type 2
diabetes compared with white Caucasians. We aimed to assess volume and activity of brown …
diabetes compared with white Caucasians. We aimed to assess volume and activity of brown …
Roux-en-Y gastric bypass surgery, but not calorie restriction, reduces plasma branched-chain amino acids in obese women independent of weight loss or the …
MA Lips, JB Van Klinken, V Van Harmelen… - Diabetes …, 2014 - Am Diabetes Assoc
OBJECTIVE Obesity and type 2 diabetes mellitus (T2DM) have been associated with increased
levels of circulating branched-chain amino acids (BCAAs) that may be involved in the …
levels of circulating branched-chain amino acids (BCAAs) that may be involved in the …
[HTML][HTML] Metabolomics based markers predict type 2 diabetes in a 14-year follow-up study
…, A van der Spek, A Verhoeven, JB van Klinken… - Metabolomics, 2017 - Springer
Background The growing field of metabolomics has opened up new opportunities for prediction
of type 2 diabetes (T2D) going beyond the classical biochemistry assays. Objectives We …
of type 2 diabetes (T2D) going beyond the classical biochemistry assays. Objectives We …
Calorie restriction is a major determinant of the short‐term metabolic effects of gastric bypass surgery in obese type 2 diabetic patients
MA Lips, GH de Groot, JB van Klinken… - Clinical …, 2014 - Wiley Online Library
Objective Roux‐en‐Y gastric bypass ( RYGB ) and restrictive weight loss interventions, such
as gastric banding ( GB ) and very‐low‐calorie diets ( VLCD ) directly impact glucose …
as gastric banding ( GB ) and very‐low‐calorie diets ( VLCD ) directly impact glucose …
[HTML][HTML] The limited storage capacity of gonadal adipose tissue directs the development of metabolic disorders in male C57Bl/6J mice
L van Beek, JB van Klinken, ACM Pronk, AD van Dam… - Diabetologia, 2015 - Springer
Aims/hypothesis White adipose tissue (WAT) consists of various depots with different adipocyte
functionality and immune cell composition. Knowledge of WAT-depot-specific differences …
functionality and immune cell composition. Knowledge of WAT-depot-specific differences …
Sex differences in body fat distribution are related to sex differences in serum leptin and adiponectin
It is debated whether sex differences in adiponectin and leptin are due to sex differences in
body fat distribution. In this cross-sectional analysis of the Netherlands Epidemiology of …
body fat distribution. In this cross-sectional analysis of the Netherlands Epidemiology of …
Anacetrapib reduces progression of atherosclerosis, mainly by reducing non-HDL-cholesterol, improves lesion stability and adds to the beneficial effects of …
…, JB van Klinken, B Simic… - European heart …, 2015 - academic.oup.com
Background The residual risk that remains after statin treatment supports the addition of
other LDL-C-lowering agents and has stimulated the search for secondary treatment targets. …
other LDL-C-lowering agents and has stimulated the search for secondary treatment targets. …
[HTML][HTML] Ether lipid transfer across the blood-brain and placental barriers does not improve by inactivation of the most abundant ABC transporters
Phospholipid transport from the periphery to the brain is an understudied topic. When certain
lipid species are deficient due to impaired synthesis, though, transfer across the blood-…
lipid species are deficient due to impaired synthesis, though, transfer across the blood-…
A 5-day high-fat, high-calorie diet impairs insulin sensitivity in healthy, young South Asian men but not in Caucasian men
…, TCM Streefland, JT Jonker, JB van Klinken… - Diabetes, 2014 - Am Diabetes Assoc
South Asians (SAs) develop type 2 diabetes at a younger age and lower BMI compared with
Caucasians (Cs). The underlying cause is still poorly understood but might result from an …
Caucasians (Cs). The underlying cause is still poorly understood but might result from an …