The mitotic spindle ensures the faithful segregation of chromosomes. Here we combine the
first large-scale serial electron tomography of whole mitotic spindles in early C. elegans …

Loop extrusion by structural maintenance of chromosomes (SMC) complexes has been
proposed as a mechanism to organize chromatin in interphase and metaphase. However, the …

The cytoskeleton forms a variety of steady-state, subcellular structures that are maintained by
continuous fluxes of molecules and energy. Understanding such self-organizing structures …

The Newton-Hooke algebras in d dimensions are constructed as contractions of dS (AdS)
algebras. Nonrelativistic brane actions are WZ terms of these Newton-Hooke algebras. The …

Spindles are arrays of microtubules that segregate chromosomes during cell division. It has
been difficult to validate models of spindle assembly due to a lack of information on the …

We have demonstrated that the two- and three-dimensional motility of the human pathogenic
parasite Entamoeba histolytica (Eh) depends on sustained instability of the intracellular …

10.7554/eLife.31149.001 Regulation of size and growth is a fundamental problem in biology.
A prominent example is the formation of the mitotic spindle, where protein concentration …

The assembly of the mitotic spindle and the subsequent segregation of sister chromatids
are based on the self-organized action of microtubule filaments, motor proteins, and other …

The mitotic spindle is a highly dynamic bipolar structure that emerges from the self-organization
of microtubules, molecular motors and other proteins. Sustained motor-driven poleward …

Optimum protein function and biochemical activity critically depends on water availability
because solvent thermodynamics drive protein folding and macromolecular interactions 1 . …